Here we establish the targeted degradation of extracellular and membrane-associated proteins using conjugates that bind both a cell-surface lysosome-shuttling receptor and the extracellular domain of a target protein. These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small ...
Here we establish the targeted degradation of extracellular and membrane-associated proteins using conjugates that bind both a cell-surface lysosome-shuttling receptor and the extracellular domain of a target protein. These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small ...
Recycling endosomes contain a fine tubular network and are involved in re-shuttling the molecules back to the plasma membrane. This is vital in protein recycling. What is Lysosome? Lysosomes are membrane bound organelles present in eukaryotic cells. Lysosomes contain acid hydrolases that have the abi...