酶替代治疗(ERT)可有效改善GL-3、Lyso-GL-3等生化指标的异常,从而增强法布雷病患者的生活质量,延长生存期2。此次大会再次强调了GL-3和Lyso-GL-3的重要性,也关注了估计肾小球滤过率(eGFR)及促炎症因子,如人巨噬细胞炎症蛋白1β(MIP-1β)和肿瘤坏死因子-α(TNF-...
长沙金域遗传生化学科的“质”慧树上”质“慧果小组在会上脱颖而出,课题《一种针对法布雷病血浆生物标志物(Lyso-GL-3)检测方法的研发》荣获湖南省第45次质量管理小组成果一等奖。 荣誉证书 法布雷病是一种罕见的X连锁遗传溶酶体贮积症,是由于GLA基因突变导致α半乳糖苷酶A(α-Gal A)活性降低或完全缺乏,造成代...
Lyso GL-3Gaucher diseaseFabry diseaseLysosomal storage disorders (LSDs) remain a significant cause of morbidity in the Indian population and treatment is largely out of reach for most patients. Although data on enzymatic and molecular diagnosis of Gaucher disease (GD) and Fabry disease (FD) in ...
In LPS3-deficient splenocytes and CD4 T cells, anti-CD3/anti-CD28-triggered IL-2 production is somewhat increased. Interestingly, LysoPS with various fatty acids was up-regulated upon T cell activation. The present study raised the possibility that LysoPS exerts its immunosuppressive roles by ...
英文别名 lysophosphatidylserine|1-octadecanoyl-sn-glycero-3-phosphoserine|CHEBI:85403|PS(18:0/0:0)|lysoPS|LPS(18:0)|lysophosphatidyl-L-serine|CHEMBL582985|GTPL4064|LysoPS(18:0/0:0)|SCHEMBL17482440|LMGP03050006|1-stearoyl-sn-glycero-3-phosphoserine|1-stearoyl-sn-gl 英文名称 lysophosphatid...
(6-carboxy-spermyl)-propylamid), Chol-Betaine (Cholesteryl-oxycarbonylmethyl-trimethyl-ammonium), DOSPA (Dioleoyloxy-sperminecarboxamido-ethyldimethyl-propanaminiumtrifluoroacetate), SAINT (Pyridinium amphiphiles analogues) and GL-67 ([Cholest-5-en-3-ol(3b)-3-[(3-aminopropyl)[4-[(3-aminopropyl)...
不仅在肝脾和外周血,Lyso-GL-1在GDⅡ型和GDⅢ型患者的大脑实质中亦均有大量贮积。GD病情严重程度与Lyso-GL-1水平存在关联,症状严重的GD患者Lyso-GL-1水平比轻症GD患者更高。CHITO由戈谢细胞产生,未治疗前表达水平通常很高,可用于监测治疗效果,对判断预后有一定的价值。并非所有GD患者CHITO活性均异常,故其用于...
Powered by Bioz See more details on Bioz Powell GL, Knowles PF, Marsh D. Spin-label studies on the specificity of interaction of cardiolipin with beef heart cytochrome oxidase. Biochemistry. 1987 Dec 15;26(25):8138-45. doi: 10.1021/bi00399a018. PMID: 2831938. PubMed ID: 2831938 Fatty...
Soderberg, C.; Stal, P.; Askling, J.; Glaumann, H.; Lindberg, G.; Marmur, J.; Hultcrantz, R. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 2010, 51, 595–602. [Google Scholar] [CrossRef] [PubMed] Ballestri, S.; Lonar...
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