magnetic-activated cell sorting; SSC, side scatter.b, UMAP plots of stroma-enriched cells from nine human MFLN samples and ten FL samples, coloured by cell type (top). Major NHC components from MFLN samples and FL samples are shown separately (bottom left and bottom...
Mudd, Ellebedy and colleagues integrate single-cell transcriptomics and TCR sequencing to characterize the spike-specific CD4+ TFH cell response in the lymph nodes and blood of BNT162b2-vaccinated and SARS-CoV-2-infected individuals up to 6 months after vaccination or infection. Nicholas Borcherdin...
Axillary lymph node statusThere is uniform agreement that the status of the axillary lymph nodes is the single most important prognostic factor for patients with breast cancer, because the disease-free and overall survival decreases as the number of positive lymph nodes increases.63...
The main cells of the lymph node paracortex are T cells The cell population of the paracortex consists of lymphocytes and accessory cells, which constantly move in and out of the region. T cells dominate the paracortex (Fig. 8.13), entering the node from the blood via the HEV and leaving...
signals, whereas the lymph nodes of all mice and the popliteal lymph nodes of four dogs that received the control substances did not show any SAE signals.Use of an intravenously administered L-selectin ligand-specific US contrast agent is feasible for active lymph node targeting in mice and ...
T- and B cell clones circulate between synovial tissue and lymph node in early stages of rheumatoid arthritis (RA): elucidating the role of lymph nodes in RA BackgroundT- and B cell receptor (TCR, BCR) mediated responses are likely to play an important role in the initiation of rheumatoid...
The microenvironment of lymph node metastasized tumors (LNMT) determines tumor progression and response to therapy, but a systematic study of LNMT is lacking. Here, we generate single-cell maps of primary tumors (PTs) and paired LNMTs in 8 breast cancer
Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear. Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single cells from 15 paired samples of primary tumors and axillary lymph nodes. We identified nine cancer cell subclusters including CD44...
Background.Patients with stage II non-small cell lung carcinoma represent a group with varying 5-year survival rates. The influence of specific types of lymph node involvement on survival was investigated.Methods.Of 2,009 patients operated on from 1977 through 1993, the cases of 391 patients wit...
To evaluate the pattern of lymph node metastasis (LNM) according to primary tumor location inT1 andT2 stage non‐small cell lung cancer (NSCLC) patients. The data of 1916NSCLCpatients withLNMwho underwent surgery with systematic nodal resection betweenNovember 2008 toDecember 2014 were included in...