The following plates (Figs. 1 and 2) are intended to provide a survey of the different cells of blood and their hematopoiesis, without commitment on as yet unsolved questions of their genesis. Solely, beginners should be enabled to find some order in the confusing variety of cells and be ...
Some types of blood cells are also made in the lymph nodes. 某些血细胞(如淋巴细胞)也是在淋巴结内形成的。 The lymphatic system also plays an important role in the body's immune system. 所以淋巴系统对于机体免疫功能十分重要。 Infection,even a tr...
Haemolymph nodes differ from ordinary lymph nodes in that their lymphatic sinuses contain many red blood cells, which are thought to pass through the walls of rather permeable venous blood vessels. Sakita et al. (1997) suggested an open circulation (see discussion of the spleen) with blood ...
CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans Mudd, Ellebedy and colleagues integrate single-cell transcriptomics and TCR sequencing to characterize the spike-specific CD4+ TFH cell response in the lymph nodes and blood of...
The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic endo
Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (mammar...
Cytotoxic T-cell clone against rectal carcinoma induced by stimulation of a patient's peripheral blood mononuclear cells with autologous cultured tumor cells In an effort to establish cytolytic T lymphocytes (CTLs) against colorectal carcinoma (CRC) by stimulating patients' lymphocytes with autologous ...
If not caught quickly, cancer cells often spread to other organs in a process called metastasis. Lymph nodes (LNs) are the organs with the highest risk of metastasis. Metastasis in the LNs also influences cancer staging and treatment planning, and their detection is correlated with an increased...
Chronic lymphocytic leukemia (CLL) is a progressive malignancy of mature B-cells that involves the peripheral blood (PB), lymph nodes (LNs) and bone marrow (BM). Although the majority of CLL cells are in a resting state, small populations of proliferating cells exist; however, the anatomical...
To address this issue, we compared the latent viruses obtained from CD4 + T cells in peripheral blood and lymph nodes to viruses emerging during treatment interruption. Latent viruses were characterized by sequencing near full-length (NFL) proviral DNA, and env from viral outgrowth cultures (VOAs...