1). As before two distinct macrophage populations, defined by MHC II expression21,22, were found in the joints (Fig. 1a). Numbers of both MHC IIlow and MHC IIhigh macrophages significantly increased with CIA, but neither showed time-of-day differences within healthy or inflamed joints (Fig...
Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8+ T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8...
the ability to present peptides to T cells; and iv) the mobilisation of dendritic cells (DC) from the epidermis towards the draining lymph nodes 1 ... A Morelli,A Larregina,E Chuluyán,... - 《Advances in Experimental Medicine & Biology》 被引量: 75发表: 1997年 Understanding the anato...
In tissue sections prepared from biopsies obtained from normal skin, ST2L+ cells with a lymphoid morphology (“ILC2-like” cells) were found in low numbers (Figure 1g, top panels). However, in healing wounds, ST2L+ ILC2-like cells were found predominantly at the wound margin within the ...
Conventional NK (cNK) cells are mainly found in peripheral blood and migrate to a specific location to exert their effects. NK cells also include tissue-resident NK (trNK) cells. The complex process of NK-cell differentiation occurs in several distinct tissues, including bone marrow, liver, thy...
Aside from lymph nodes, where would you expect to find proliferating (dividing) B cells?Besides lymph nodes, where would you expect to find proliferating (dividing) B cells? in the brain in the thyroid in the skin in the spleenLangerhan cells are found in ___. (a) ski...
During the later course eDCs were found in lymph nodes, Peyer's patches, spleen, and thymus for a period of up to 6 weeks after transfer. Nonmyeloablative or myeloablative conditioning did not affect migration patterns and in both settings intravenous injection of eDCs did not induce GvHD. ...
Methods We vaccinated neonatal C57BL/6 mice with BCG in a mouse model of asthma and analyzed the expression and function of Th1 cells in vivo and in vitro. Results BCG vaccinationinduced Th1 cells in the local inguinal lymph nodes (ILN) migrated into the lungs upon inhaled ovalbumin (OVA)...
(FDCs). Non-haematopoietic stromal cells found in B cell follicles that have an important role in antigen presentation to B cells. Lymphoid tissue organizer cells (LTo cells). CXC-chemokine ligand 13 (CXCL13)+ lymphotoxin-β receptor (LTβR)+ podoplanin (PDPN)+CD45− mesenchymal stromal ...
(Extended Data Fig.4i), which is consistent with their proposed role in facilitating immune cell migration. AGT+cells were found on outer regions of the IFRs, frequently situated between SCSs and HEVs (Extended Data Fig.4j). SMCs were observed as α-smooth muscle actin+(encoded byACTA2),...