ARTICLES Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes Heather D Hickman1, Kazuyo Takeda1, Cara N Skon1, Faith R Murray1, Scott E Hensley1, Joshua Loomis2, Glen N Barber2, Jack R Bennink1 & Jonathan W Yewdell1 It is uncertain how ...
The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our understanding of lymphoma NHCs has been hampered by unexplained NHC heterogeneity, even in normal human lymph nodes (LNs). ...
Two axillary lymph nodes from a patient who underwent modified radical mastectomy for carcinoma of the breast showed benign nevus cells in the fibrous capsule and within afferent lymphatics. Subsequently, an intradermal nevus from the area of drainage of the axillary lymph nodes was excised, which...
(a) Frequencies of ILCs in the draining lymph nodes. Populations depicted are gated on live, CD45+ Lin− lymphocytes (n = 4/group). (b) Representative images of wounds at indicated times. (c) Quantification of wound healing, expressed as percent of original wound size. (d) ...
ObjectiveWe previously reported that the largest diameter of retrieved lymph nodes (LNs) correlates with the number of LNs and is a prognostic factor in stage II colon cancer. We examine whether T, B, and natural killer (NK) cells in LNs are related to the number of LNs and survival.关键...
NK cells in the lymph nodes play important roles in inhibiting tumor metastasis into draining lymph nodes. Previously, we reported that chronic alcohol consumption interferes with NK cell trafficking from the bone marrow to the spleen. Herein, we found that alcohol consumption decreases the numbers ...
Aside from lymph nodes, where would you expect to find proliferating (dividing) B cells?B Cells:B cells are a type of white blood cells and are also known as B lymphocytes. Hematopoietic stem cells develop B cells. B cells produce antibodies against the antigen and also develop...
T cells are imprinted to express tissue-specific homing receptors upon activation in tissue-draining lymph nodes, resulting in their migration to the site of Ag entry. Expression of gut-homing molecules alpha(4)beta(7) and CCR9 is induced by retinoic acid, a vitamin A metabolite produced by ...
Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis ArticleOpen access18 April 2022 Introduction Regulatory T cells (Tregs) are a unique leukocyte subset that does not protect from infectious agents but controls activation of other immune cells. Despite Tregs account ...
cells in lymph nodes (LNs) predict disease-free survival12. In lung and liver cancer, high CD4:CD8 T-cell ratios were associated with good prognosis13,14. However, CD4+T cells may also suppress antitumour immunity15. To clarify the mechanism of cancer prevention by CD4+T cells, we have ...