The first panel shows the number of patients in the evaluation given the threshold; the second and third panels show the corresponding Pearson r and two-tailed p value (shown as -log10(p)). Extended Data Fig. 6 Evaluating the predictive capacity and information overlap among the TGSig, SLE...
Lupus nephritis (LN) is an immune complex glomerulonephritis that affects about half of patients with systemic lupus erythematosus (SLE). Patients who develop LN in the setting of SLE have a worse prognosis overall and can develop chronic or end-stage kidney disease. Effective therapies have been ...
Panel c auto-antibody titers be- fore and after rituximab. Panel d serum complements as C3 and C4 complements. Asterisks in- dicate significant differences from the post-rituximab values; P < 0.01 417 developed symptoms of cerebral vasculitis, with seizures and a cerebral infarct, demonstrated by...
Alternatively, a panel of autoantibodies, possibly combined with cytokines and gene expression levels, might be useful. The skewed demographics of SLE can also be exploited, including the higher prevalence in females, first- degree relatives and individuals < 40 years old, permitting focus on those...