Tolerance is a state of adaptation in which exposure to a drug induces changes that result in a diminution of one or more of the drug’s effects over time. Tolerance may occur to both the desired and undesired effects of drugs and may develop at different rates for different effects. ...
In healthy subjects, the pharmacokinetic profile was examined after single doses of up to 7.5 mg and after once-daily administration of 1, 3, and 6 mg for 7 days. Eszopiclone is rapidly absorbed, with a time to peak concentration (tmax) of approximately 1 hour and a terminal-phase ...
Eszopiclone's acceptable side-effectprofile and effectiveness are similar tothose of other available sleep aids andare supported by 6 months of clinicaltrials. As the only nonbenzodiazepinestudied for this long, eszopicloneshows promise for patients withchronic and transient insomnia,including elderly pati...
Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta (R)) and its effect on total sleep time, headache frequency, and daytime functioning: A randomized, double-blind, placebo-controlled, parallel-group, pilot studyInsomnia...