血管内皮细胞-免疫细胞相互作用是否负责ALI期间STING介导的肺炎症，因此，仍有待探索。1.cGAS-STING通路在LPS诱导的ALI小鼠模型中被上调，STING抑制剂下调其激活 内毒素诱导的ALI是一个由促炎激活免疫细胞和增加血管通透性介导的非致命ALI的明确模型。在作者的研究中，作者使用LPS诱导的ALI模型（图1a）研究了STING在肺炎...
1.cGAS-STING通路在LPS诱导的ALI小鼠模型中被上调,STING抑制剂下调其激活 内毒素诱导的ALI是一个由促炎激活免疫细胞和增加血管通透性介导的非致命ALI的明确模型。在作者的研究中,作者使用LPS诱导的ALI模型(图1a)研究了STING在肺炎进展中的潜在作用。STING抑制剂在模型每次雾化前30分钟腹腔注射。结果显示,LPS处理组肺组...
1.cGAS-STING通路在LPS诱导的ALI小鼠模型中被上调,STING抑制剂下调其激活 内毒素诱导的ALI是一个由促炎激活免疫细胞和增加血管通透性介导的非致命ALI的明确模型。在作者的研究中,作者使用LPS诱导的ALI模型(图1a)研究了STING在肺炎进展中的潜在作用。STING抑制剂在模型每次雾化前30分钟腹腔注射。结果显示,LPS处理组肺组...
目的探讨利多卡因(Lidocaine,Lido)通过调节环鸟苷酸-腺苷酸合成酶(Cyclic guanosine monophosphate synthase,cGAS)-干扰素基因刺激因子(Stimulator of interferon genes,STING)信号通路对脂多糖(lipopolysaccharide,LPS)诱导的小胶质细胞炎性损伤的影响及其作用机制.方法0~200μg/mL的利多卡因处理LPS诱导的BV2小胶质细胞...
目的探讨利多卡因(Lidocaine,Lido)通过调节环鸟苷酸-腺苷酸合成酶(Cyclic guanosine monophosphate synthase,cGAS)-干扰素基因刺激因子(Stimulator of interferon genes,STING)信号通路对脂多糖(lipopolysaccharide,LPS)诱导的小胶质细胞炎性损伤的影响及其作用机制.方法0~200μg/mL的利多卡因处理LPS诱导的BV2小胶质细胞24...
与研究者减轻RUNX1 IE小鼠肺部线粒体损伤的发现一致,cGAS、STING和NLRP3的蛋白质水平显著降低。LPS损伤后,IE-RUNX1小鼠BALF中炎症细胞数量显著减少,这与促炎细胞因子减少有关,包括IFN-α、IFN-β、IL-1β、IL-18、IL-6和TNF-α。这些数据支持了AT2中RUNX1依赖性线粒体自噬激活保护肺免受LPS损伤的结论。
Cytoplasmic nucleic acids sensing through cGAS-STING-TBK1 pathway is crucial for the production of antiviral interferons (IFNs). IFN production can also be induced by lipopolysaccharide (LPS) stimulation through Toll-like receptor 4 (TLR4) in appropriate conditions. Of note, both IFN production and...
Microglia are the resident immune cells of the CNS that are activated in response to a variety of stimuli. This phenotypical change is aimed to maintain the local homeostasis, also by containing the insults and repair the damages. All these processes are tightly regulated and coordinated and a ...
cGAS-STING pathwayInflammasomeAcute lung injurySynergistic effectEthnopharmacological relevance Shuangdan Jiedu Decoction (SJD) is a formula composed of six Chinese herbs with heat-removing and detoxifying, antibacterial, and anti-inflammatory effects, which is clinically used in the therapy of various ...
Conclusion: We demonstrated that ALDH2 alleviated LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING signaling pathway, thereby protecting against LPS-induced cardiac injury. This study identifies a novel therapeutic approach for treating sepsis-induced cardiomyopathy (SIC)....