Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century, it suffers from high intra- and inter-observer variability and does not adequately predict clinical outcomes. Based on integrated analysis of multiplatform genomic data from The Cancer ...
A better understanding of the association between these subtypes and GII/IIIs could further knowledge regarding prognosis and mechanisms of glioma progression. 展开 关键词: Gene expression Glioma Histology DNA methylation Astrocytoma Oligodendroglioma Survival analysis Open data DOI: 10.1371/journal.pone....
OBJECT: Glioma resection under conscious ("awake") sedation (CS) is used for eloquent areas of the brain to minimize postoperative neurological deficits. T... P Peruzzi,SD Bergese,A Viloria,... - 《Journal of Neurosurgery》 被引量: 64发表: 2011年 Intrinsic tectal low grade astrocytomas: ...
gliomaisocitrate dehydrogenaseMRIsubventricular zoneBACKGROUND AND PURPOSE Glioblastomas (GBMs) that involve the subventricular zone (SVZ) have a poor prognosis, possibly due to recruitment of neural stem cells. The purpose of this study was to evaluate whether SVZ involvement by lower grade gliomas ...
Single-cell profiling uncovers proliferative cells as key determinants of survival outcomes in lower-grade glioma patients doi:10.1007/s12672-024-01302-8Artificial intelligenceSingle-cell RNA sequencingImmunotherapyPrognosisLower-grade gliomas (LGGs), despite their generally indolent clinical course, are ...
low grade gliomaPCVradiotherapytemozolomideThe majority of patients with high‐risk lower grade gliomas (LGG) are treated with single‐agent temozolomide (TMZ) and radiotherapy despite three randomized trials showing a striking overall survival benefit with adjuvant procarbazine, lomustine, and vincristine...
Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth. However, the molecular mechanisms of CNTFRα regulation and its clinical significance in glioma rema
脑医汇愿成为临床神经科学领域领先的新媒体、医生线上教育、医学传播及数字营销、患者随访管理、远程转诊会诊、临床招募及真实世界数据、技术转化孵化平台。推动中国脑疾病诊疗规范化,共建强大的临床神经科学数字生态。
The expression levels of eight lncRNAs can be combined to produce a prognostic tool applicable to diverse populations of glioma patients. The 8 lncRNA (UVA8) based score can identify grade II and grade III glioma patients with poor outcome, and thus identify patients who should receive more ...
Deletion and low expression of NFKBIA are associated with poor prognosis in lower-grade glioma patientsLower-grade gliomas (LGGs), which are uniformly fatal in young adults, are classified as grades II-III tumors according to their histological features. The NFκB transcription factor, a crucial ...