Although the histopathologic classification of lower-grade glioma has been the accepted standard for nearly a century, it suffers from high intra- and inter-observer variability and does not adequately predict clinical outcomes. Based on integrated analysis of multiplatform genomic data from The Cancer ...
gliomaisocitrate dehydrogenaseMRIsubventricular zoneBACKGROUND AND PURPOSE Glioblastomas (GBMs) that involve the subventricular zone (SVZ) have a poor prognosis, possibly due to recruitment of neural stem cells. The purpose of this study was to evaluate whether SVZ involvement by lower grade gliomas ...
low grade gliomaPCVradiotherapytemozolomideThe majority of patients with high‐risk lower grade gliomas (LGG) are treated with single‐agent temozolomide (TMZ) and radiotherapy despite three randomized trials showing a striking overall survival benefit with adjuvant procarbazine, lomustine, and vincristine...
High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: a retrospective analysis of 1... Conventional treatment of high-grade glioma includes maximal surgical resection followed by external radiation therapy. Despite this treatment, the pr...
Lower-grade gliomas (LGGs), despite their generally indolent clinical course, are characterized by invasive growth patterns and genetic heterogeneity, which can lead to malignant transformation, underscoring the need for improved prognostic markers and therapeutic strategies. This study utilized single-cell...
The intent was to evaluate the relevance of known glioblastoma (GBM) expression and methylation based subtypes to grade II and III gliomas (ie. lower grade gliomas). Gene expression array, single nucleotide polymorphism (SNP) array and clinical data were obtained for 228 GBMs and 176 grade II...
Glioma is one of the most common primary brain tumors. Despite surgical resection and chemo-radiotherapy, the prognosis of glioblastoma (GBM) patients remains dismal. Lower grade gliomas (LGG) inevitably progress to high grade. A hallmark of GBM is the acquisition of self-sufficient growth factor...
脑医汇愿成为临床神经科学领域领先的新媒体、医生线上教育、医学传播及数字营销、患者随访管理、远程转诊会诊、临床招募及真实世界数据、技术转化孵化平台。推动中国脑疾病诊疗规范化,共建强大的临床神经科学数字生态。
Lower grade gliomas GBM: Glioblastoma multiforme CNS: Central nervous system TCGA: The Cancer Genome Atlas CGGA: Chinese Glioma Genome Atlas HR: Hazard ratio PFS: Progression-free survival IFNG: Interferon gamma Cindex: Concordance index AUC: Area under curve ROC: Receiver operating ...
For a long time, the guidance for adjuvant chemoradiotherapy for lower grade glioma (LGG) lacks instructions on the application timing and order of radiotherapy (RT) and chemotherapy. We, therefore, aimed to develop indicators to distinguish between the different beneficiaries of RT and chemotherapy,...