(TL) controls and adult vascular-dependent pathologies, including brain vascular malformations, namely, brain AV malformation (AVM)36,42, and brain tumours, notably, lower-grade glioma (LGG)22,43, glioblastoma (GBM)22,44,45, lung cancer brain metastasis (MET)22,46 and meningioma (MEN)47 (...
由复旦大学附属华山医院神经外科吴劲松教授团队历时12年,在今年1月于《European Journal of Cancer(欧洲癌症杂志)》上发表文章《Effect of high-field iMRI guided resection in cerebral glioma surgery: A randomized clinical trial(高场强术中磁共振在脑胶质瘤手术中效应:随机对照验证试验)》,该临床试验是第一个精心...
2) Grade of gliomas 脑胶质细胞瘤分级 3) BGSCs 脑胶质瘤干细胞 1. BACKGROND&OBJECTIVE: To sort brain glioma stem cells(BGSCs) from glioma cell lines and fresh glioma specimens, culture in vitro and identify its character as a stem cell. 背景与目的:脑胶质瘤治疗效果一直不理想,这与胶质...
Technological advancements in molecular analysis, including single cell sequencing, now allow us to assess alterations in specific cell types in the brain tumor microenvironment, which can enhance the development of novel therapies that target glioma growth and glioma-induced neurologic symptoms....
8e). Because an RNA-seq database for lung cancer brain metastasis is currently unavailable, we tested the TME network markers with a cohort of low-grade glioma (LGG, n = 515, TCGA), which has been shown recently to share many common TME features with BrMs16. We found that ...
Based on thepatient's MRI, a radiologist could not differentiate whether itis a low grade Glioma or a high grade Glioma. Because bothof these are almost visually similar, autopsy confirms thediagnosis of low grade with high-grade and infiltrativefeatures. In this paper, textural description of ...
Glioblastoma (GBM), the highest grade glioma (grade IV), is one of the most frequent malignant primary tumors in the central nervous system in adults [43]. Despite surgical resection followed by chemotherapy and radiotherapy, a patient’s median survival remains no more than 15 months after ini...
Transcript expression, correlation, and overall survival (OS) analyses were evaluated using public datasets available on GEPIA2 in Glioblastoma (GBM) and Lower Grade Glioma (LGG) cohorts. Results Seven out of ten markers showed a significantly different IHC expression in at least one of the ...
tumors and other CNS tumors, and focuses on the significant molecular signal pathway and currently considered therapeutic options (clinical trials, targeted therapies, immunotherapies, and system therapies) in glioma, meningioma, primary CNS lymphoma, and CNS germ cell tumors, setting by the WHO CNS5...
single-cell RNA sequencing (scRNA-seq) of CD11b+myeloid cells in naïve and GL261 glioma-bearing mice that reveal distinct profiles of microglia, infiltrating monocytes/macrophages and CNS border-associated macrophages. We demonstrate an unforeseen molecular heterogeneity among myeloid cells in naïve...