Low-grade gliomasHLA-DRAGliomaImmuneTEMBiomarkerBackground:Low-grade gliomas (LGG) are WHO grade II tumors presenting as the most common primary malignant brain tumors in adults. Currently, LGG treatment involves either or a combination of surgery, radiation therapy, and chemotherapy. Despite the ...
Lower-grade gliomas (LGGs) exhibit highly variable clinical behaviors, while classic histology characteristics cannot accurately reflect the authentic biological behaviors, clinical outcomes, and prognosis of LGGs. In this study, we carried out analyses of whole exome sequencing, RNA sequencing and DNA...
Significant advancements in neurosurgical planning, approach, and practice over the past five decades have improved the surgical management of diffuse low and high-grade gliomas. We sought to evaluate the extent to which LGG survival outcomes have evolved over the past fifty years using glioma ...
Approximately 4% of all gliomas occur in the brainstem [1]. Brainstem gliomas tend to affect children and young adults and comprise a heterogeneous group of neoplasms. Brainstem gliomas have the worst prognosis of any childhood brain tumor, but subsets of brainstem gliomas—including NF-1-associate...
The poor prognosis of gliomas necessitates the search for biomarkers for predicting clinical outcomes. Recent studies have shown that PANoptosis play an important role in tumor progression. However, the role of PANoptosis in in gliomas has not been fully clarified.Low-grade gliomas (LGGs) from TCG...
Bruner JA (1987) Oligodendroglioma: diagnosis and prognosis. Semin Diagn Pathol 4:251–61 PubMedCASGoogle Scholar Bruner JM (1994) Neuropathology of Malignant gliomas. Semin Oncol 21:126–38 PubMedCASGoogle Scholar Ludwin SK (1997) The pathobiology of the oligodendrocyte. J Neuropathol Exp Neurol...
Low grade gliomas are the most frequent brain tumors in children and encompass a spectrum of histologic entities which are currently assigned World Health Organisation grades I and II. They differ substantially from their adult counterparts in both their
Thus, the immune role of FAM109B in low-grade gliomas may be attributed to TAMs. TAM infiltration is closely associated with poor prognosis in cancer patients, and targeting TAMs is a potentially attractive therapeutic strategy [35]. Genomic variations play a critical role in tumor immune ...
long non-coding RNARP3-525N10.2-NFKB1-PROS1triplet-mediatedPROS1expression could serve as a biomarker for cancer diagnosis, prognosis, therapy selection, and follow-up in LGG patients. Introduction Glioma is the most common malignancy in the brain. Low-grade gliomas (LGGs, grade II and III...
The 5-year CSS and progression-free survival declined significantly to 84% and 67% for patients with tumors demonstrating any degree of Ki-67 positivity (p = 0.005 and p = 0.006, respectively).#Ki-67 is a useful predictor of CSS in low-grade gliomas; however, it is not independent of ...