Low-grade gliomas are a heterogeneous group of tumors that overall have a better prognosis than WHO grade III and IV tumors. However, these tumors can devastate a child because of progression in proximity to critical structures, or the long-term consequences of therapy. Observation after complete...
low-grade glioma. In doing so we discuss the specific molecular drivers of pediatric low grade glioma and how to effectively test for them, review the newest therapeutic agents and their utility in treating this disease, and propose a risk-based stratification system that considers both clinical a...
low-grade glioma. In doing so we discuss the specific molecular drivers of pediatric low grade glioma and how to effectively test for them, review the newest therapeutic agents and their utility in treating this disease, and propose a risk-based stratification system that considers both clinical a...
Fatty acid metabolism disruptions affect low-grade gliomas (LGGs), with glioma cells depending on fatty acids for survival. Targeting fatty acid oxidation through the acyl-coenzyme A synthetase long-chain (ACSL) family could alleviate glioma growth and improve prognosis management. However, the integr...
Broniscer A, Baker SJ, West AN, Fraser MM, Proko E, Kocak M, Dalton J, Zambetti GP, Ellison DW, Kun LE, Gajjar A, Gilbertson RJ, Fuller CE (2007) Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 25:682–689. https:...
. Abbreviations PA: Pilocytic astrocytoma; WHO: World Health Organization; LGG: Low Grade Glioma; DIA: Desmoplastic infantile astrocytoma; DIG: Desmoplastic infantile ganglioglioma; GG: Ganglioglioma; FA: Diffuse fibrillary astrocytoma; CNS: Central nervous system; NF1: Neurofibromatosis type 1; RLS: ...
Glioneuronal tumors are somewhat related given that a low-grade glioma component is frequent and they are also characterized by similar demographics. The prognosis for these tumors is generally good, but complete surgical resection may not be possible in specific locations, therefore they have a ...
of tumors and predict the prognosis of patients with glioma (4). miRNAs are single-stranded non-coding RNAs and usually 18-25 nucleotides in length. Mostly miRNAs are combined with the 3' end of the untranslated regions (3'UTR) of target mRNAs, resulting in their degradation or inhibition ...
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6 The Tp53-null background in PMAs, although alone insufficient to drive oncogenesis,6 provides a primary, glial cellular context poised for transformation and testing of glioma-associated CRAF fusions. We also use NIH3T3s that have been predictive of oncogenic transformation and clinical response ...