High-grade gliomasSystematic reviewHigh-grade gliomas are the most common intracranial malignancies, and their current prognosis remains poor despite standard aggressive therapy. Charged particle beams have unique physical and biological properties, especially high relative biological effectiveness (RBE) of ...
high grade gliomaimagingThe treatment options and prognosis in gliomas could be determined by anatomic topographic location, beside different subtypes of glioma. The aim of this study is to find if any correlation between anatomical location of a glioma and the different subtypes of high grade ...
Depending on their location, gliomas can also drastically impair or disrupt vital functions. In children, these tumors can develop in midline structures like the brainstem (e.g., diffuse intrinsic pontine gliomas or DIPG), and due to their anatomic location, they are often unresectable and ...
high grade gliomasmalignant gliomaradioimmunotherapytumor necrosis therapyINTRODUCTION: Despite treatment advances for malignant gliomas in adults, prognosis remains poor, largely due to the infiltrative and heterogeneous biology of these tumors. Response to adjuvant therapy is not always uniform and the ...
Gliomas are the most commonly occurring brain tumor in adults, and despite therapeutic advancements, high-grade gliomas have a near-universal fatality rate.Citation18,Citation19As such, it is imperative to identify effective prognostic biomarkers that can accurately predict the prognosis of high-grade ...
High-grade gliomas (HGGs) are vascular tumors that represent attractive targets for antiangiogenic therapies. In this Review, we present the rationale and clinical trial evidence for targeting angiogenesis in HGGs, focusing predominantly on agents that target vascular endothelial growth factor (VEGF) ...
However, in lower grade IDH-mutated tumours, MGMT methylation identifies a sub-population with a better prognosis irrespective of the applied treatment [18]. The determination of these markers is now part of routine practice; however, whether MGMT methylation status determination is carried out for ...
(REMBRANDT), epitranscriptomic regulators appear to be differentially expressed based upon molecular alterations and clinical attributes. For example, METTL3, FTO, and YTHDC1 are significantly differentially expressed between IDH-mutant and IDH-wildtype high grade gliomas [44]. Additionally, m6A writer ...
While morphologically low grade gliomas (LGG; WHO grades 1, 2) have an excellent prognosis in children, higher grade gliomas (HGG; WHO grades 3, 4) continue to have dismal outcomes [4]. Molecular reclassification and subgrouping of pediatric HGG has proved to be useful for clinical ...
High-grade gliomas (HGGs) are central nervous system (CNS) tumors that occur in both children and adults, although bear distinct molecular features and neuroanatomy in younger compared with older patients [1,2,3,4]. While these types of cancers are relatively rare, patient prognosis is quite ...