Low dose TamOxifen and LifestylE changes for bReast cANcer prevention (TOLERANT study): Study protocol of a randomized phase II biomarker trial in women at increased risk for breast cancerdoi:10.1371/journal.pone.0309511LOW-calorie dietBREAST cancer...
The results of their study show that tamoxifen decreased the expression of the proliferation marker Ki-67 in breast tissue at all doses tested and that there was no difference in the magnitude of this reduction between the different doses. At the same time, a statistically significant dose ...
Wild-type erbB-2/neu transgenic mice were used to study the interactions between tamoxifen and dietary phytoestrogens (or isoflavones) by dose and form in vivo. Mice were randomized to one of four dietary formulas and implanted with an 8-week continuous-release tamoxifen or placebo pellet at 8...
This study evaluates, compares, and contrasts the effects of three selective estrogen receptor modulators (SERMs), namely, tamoxifen, toremifene, and raloxifene, on the hypothalamic-pituitary-testicular axis in 284 consecutive subfertile men with idiopathic oligozoospermia using three therapeutic protocols...
spatial memory in a similar manner as 17b-estradiol (Luine et al, 2003), similar to findings in this study. Interestingly, Different Forms of Estradiol Influence Hippocampus- Dependent Contextual Fear Conditioning in a Dose-Dependent Manner 17a-estradiol is a more potent inducer of CA1 pyramidal ...
4801 An enhancement of breast cancer risk reduction by tamoxifen (T) was observed in hormone replacement therapy users in the Italian tamoxifen trial. Based on this observation we conducted a ranging low dose tamoxifen randomised phase II trial in healthy postmenopausal women. Our goal is to reach...
There has been some concern that the interplay between leaf motion during the delivery of IMRT and tumor motion might lead to regions of underdosing. A study attempting to assess the magnitude of this effect found that during the course of a 30-fraction treatment schedule, the delivery dose wa...
The low dose of LNG released accounts for the low hormonal side-effect rate and virtual absence of amenorrhoea in premenopausal women. The system has not yet been evaluated in tamoxifen users (to protect the endometrium), or in women with rectovaginal endometriosis. However, early indications ...
161 However, these early studies involved oral contraceptives that contained relatively high doses of hormones, as opposed to the low-dose estrogen preparations used currently. The World Health Organization (WHO) has performed the largest case-control study of oral contraceptive use and stroke risk....
For a long time, scientists considered genotoxic effects as the major issue concerning the influence of environmental chemicals on human health. Over the last decades, a new layer superimposed the genome, i.e., the epigenome, tremendously changing this p