Decensi, Oral low dose and topical tamoxifen for breast cancer prevention: modern approaches for an old drug, Breast Cancer Res. 14 (2012) 214.Lazzeroni M, Serrano D, Dunn BK, et al. Oral low dose and topical tamoxifen for breast cancer prevention: modern approaches for an old drug. ...
Many studies have demonstrated the utility of tamoxifen for the treatment of estrogen receptor (ER)-positive breast cancer (1) and more recently for the prevention of breast cancer in women at increased risk (2-4). However, the toxicities of tamoxifen such as thromboembolic events and endometrial...
Interestingly, contex- a function for estradiol in contextual fear conditioning, tual fear conditioning is reliant on an intact, functioning although to date, it is not known whether a dose-dependent dorsal hippocampus as seen from lesion and immediate effect of estradiol exists for contextual fear ...
Chemotherapy should be utilized as appropriate based upon documented clinical risk group at the time of diagnosis • Immunomodulatory therapies such as ACTH,prednisone, dexamethasone and low-dosecyclophosphamidehave been utilized for treatment • ...
Anastrozole (Arimidex) is an alternative therapy to tamoxifen in women with endocrine responsive breast cancer. Its advantage in the genital tract is that it reverses the endometrial changes produced by tamoxifen and reduces the need for hysteroscopy.80 The mean reduction in endometrial thickness after...
For a long time, scientists considered genotoxic effects as the major issue concerning the influence of environmental chemicals on human health. Over the last decades, a new layer superimposed the genome, i.e., the epigenome, tremendously changing this p
4801 An enhancement of breast cancer risk reduction by tamoxifen (T) was observed in hormone replacement therapy users in the Italian tamoxifen trial. Based on this observation we conducted a ranging low dose tamoxifen randomised phase II trial in healthy postmenopausal women. Our goal is to reach...
(R26tdTomato)29. After exclusively labeling terminally differentiated proximal tubular epithelia by high-dose tamoxifen injection, the mice were administered 10 mg/kg of cisplatin or saline intraperitoneally once a week for four weeks and euthanized 28 days after the last cisplatin injection (Fig.5a)...
clinical research, which included the role of CBE and breast self‐examination as an alternative to radiological screening in areas of limited resources, the interval and methodology of BC surveillance in women with increased risk of BC and the use of low dose tamoxifen in BC risk reduction. In...
Tamoxifen can cause marked hypertriglyceridemia and has been associated with chylomicronemia syndrome and pancreatitis.111 Raloxifene reduces LDL cholesterol similarly to estrogen, but in patients with a history of hypertriglyceridemia with oral estrogen, raloxifene can be associated with severe ...