PiMheerlen a PiM allele resulting in very low α(alpha) 1 -antitrypsin serum levels. Hum Genet. 1981;59:104–7.Kramps JA, Brouwers JW, Maesen F, Dijkman JH (1981): Pi Mheerlen , a Pi M allele resulting in very low α 1 -antitrypsin serum levels. Hum Genet 59 : 104–107...
Fig. 1 A Analysis of serum Glycoproteins. Plasma samples from normal subject (N), and the patient (P) were submitted to SDS PAGE followed by Western-blot analysis of 4 seric glycoproteins: Haptoglobin (HPT), Orosomucoid (ORO), alpha-antitrypsin (AAT) and transferrin (TRF). The molecular we...
We also observed fragments of much larger proteins known to play a physiological role including the C terminus of alpha1-antitrypsin (SERPINA1), or SPAAT, which regulates neutrophil extracellular trap (NET) formation (31). To fully characterize the components of this fraction, we performed ...
Alpha-1-antitrypsin, S100A9 and gastric intrinsic factor have been proposed as biomarkers in gastric fluid (Hsu et al, 2007; Wu et al, 2012), whereas alpha-defensins (Kim et al, 2010) and Cathepsin B (Ebert et al, 2005a) have been identified from tissue analysis. Other recently ...
Ig kappa chain C region), and the enrichment of either apolipoproteins (A-I, A-II, A-IV, C-III and D) or others proteins of low molecular weight, such as alpha-1-antitrypsin (~46 kDa) and haptoglobin (~45 kDa). Furthermore, glycosylated proteins were also identified using this deple...
The amounts of alpha 1 antitrypsin protein are reduced in the vascular wall of the acutely dissected human ascending aorta. Eur. J. Cardiothorac. Surg. 2010, 37, 684–690. [Google Scholar] [CrossRef] [Green Version] Allaire, E.; Schneider, F.; Saucy, F.; Dai, J.; Cochennec, F....
Serum alpha 1-acid glycoprotein and the binding of drugs in obesity. Br. J. Clin. Pharmacol. 1983, 16, 751. [Google Scholar] [CrossRef] [Green Version] Kim, S.W.; Choi, J.-W.; Yun, J.W.; Chung, I.-S.; Cho, H.C.; Song, S.-E.; Im, S.-S.; Song, D.-K. ...
With serum, the number resolved is much lower because of the presence of large amounts of albumin, transferrin, haptoglobin, α2-HS glycoprotein, α1-antitrypsin, Gc globulin, α1 acid glycoprotein (orosomucoid), and Ig chains. For urine, similar problems exist due to the presence of IgG, ...
and antitrypsin, whereas Human 14 removes the high and intermediate abundant proteins by binding the six proteins indicated above plus alpha-2-macroglobulin, alpha-1-acid glycoprotein, IgM, apolipoprotein AI, apolipoprotein AII, complement C3 and transthyretin. These immunoaffinity steps provide the inter...
Six of these proteins, namely serum albumin, Keratin Type II Cytoskeletal 1, IgG gamma chain-1, GAPDH, alpha-1 antitrypsin and ApoA-I, were down-regulated in the KC samples in comparison with the controls. In addition, we detected up-regulation of lysozyme C, keratin type I cytoskeletal ...