Low alpha-1-antitrypsin (AAT) levels are known to be associated with liver disease. As AAT is also synthesised in the liver, we investigated whether liver disease itself may result in low AAT levels. AAT was measured in plasma...
MIA1101 detects Alpha1-Antitrypsin which has a predicted molecular weight of approximately 46 kDa.MIA1101 was formerly sold as a Seradyn product. 靶标信息 Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chym...
alpha1-Antitrypsin (alpha1AT) provides the major protection in the lung against neutrophil elastase-mediated proteolysis. Inheritance of alpha1AT deficiency alleles is associated with an increased risk of emphysema and liver disease. alpha1AT null alleles cause the total absence of serum alpha1AT an...
alpha 1-antitrypsin (AAT) deficiency is an inherited condition characterized by low serum levels of AAT and an increased risk of developing pulmonary emphysema. The disease occurs mainly in Caucasians, but Southern Europe, including Ital... M Luisetti,G Massi,M Massobrio,... - 《Respir Med》...
PiSZ: 40% of normal serum level of A1AT PiZZ: 10-15% (severe alpha 1-antitrypsin deficiency) M is the most common allele, accounting for 95% of those found in Caucasian people whereas S and Z are the most common mutant alleles. ...
The calculated synthesis rate of α 1 -antitrypsin was about twice as high in the patient as in the controls. Therefore, both a longer half-life and an increased synthesis rate contribute to the high level of α 1 -antitrypsin in the plasma of the analbuminemic patient. 展开 关键词: An...
(Biochemistry) a protein that forms in the liver of the human fetus. Excessive quantities in the amniotic fluid and maternal blood may indicate spina bifida in the fetus; low levels may point to Down's syndrome. Abbreviation:afp Collins English Dictionary – Complete and Unabridged, 12th Edition...
A Review of α_1-Antitrypsin Deficiency A serum AAT level of 11 jjiM represents the protective threshold value below which the risk of emphysema is believed to increase. In addition to the ... JK Stoller,LS Aboussouan - 《American Journal of Respiratory & Critical Care Medicine》 被引量:...
Alpha-1 antitrypsin deficiency is an autosomal co-dominant disorder caused by mutations of the highly polymorphic SERPINA1 gene. This genetic disorder still remains largely under-recognized and can be associated with lung and/or liver injury. The laborat
Alpha1-antitrypsin deficiency (AATD) was first described by Laurell and Eriksson in 1963. Laurell noted the absence of the band of alpha1- protein in 5 of 1500 serum protein electrophoreses (SPEP) submitted to his laboratory in Sweden.