Alpha-1 Antitrypsin (AAT) is a 52 kDa glycoprotein that is principally synthesized by the liver. It is the archetype of the ser-ine protease inhibitor (Serpin) superfamily of proteins, which has a major role in inactivating neutrophil elastase and other proteases to retain protease-antiprotease ...
Low Serum Alpha-1 Antitrypsin (AAT) in Family Members of Individuals with Autism Correlates with PiMZ Genotype.AimDeficiency of Alpha-1-antitrypsin (AAT) can be a genetic condition that increases the risk of developing liver, lung and... AJ Russo,L Neville,C Wroge - 《Biomarker Insights》 ...
Production of alpha-1-antitrypsin (AAT) by human monocytes is an important factor in controlling tissue damage by proteases in the microenvironment of inflammation. Increases, of four- to eightfold, in numbers of macrophages and levels of AAT and its cleavage fragments have been found in various ...
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Alpha-1-antitrypsin augmentation therapy for alpha-1-antitrypsin deficiency Alpha-1-antitrypsin (A1AT) deficiency is a genetic disorder characterized by low serum levels of A1AT and a high risk for the development of emphysema. A1A... Richard,C.,Hubbard,... - 《American Journal of Medicine》...
alpha1-Antitrypsin (alpha1AT) provides the major protection in the lung against neutrophil elastase-mediated proteolysis. Inheritance of alpha1AT deficiency alleles is associated with an increased risk of emphysema and liver disease. alpha1AT null alleles cause the total absence of serum alpha1AT an...
ALPHA-1-ANTI-TRYPSIN Antibody is specific for alpha-1-anti-trypsin. Alpha 1-Antitrypsin or α1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily and is generally known as serum trypsin inhibitor. Alpha-1-anti-trypsin protects tissues from enzymes of inflammatory cells...
There are over 70 genetic variants of alpha-1-antitrypsin, with the Z allele being of greatest clinical relevance. Individuals homozygous for this allele (approximately one in 2500 in Caucasians) have low serum alpha-1-antitrypsin levels (10–20% of normal) and are predisposed to emphysema, ...
The abnormality of the S variant of human α-1-antitrypsin Background and Aim: Patients suspected of Alpha 1-Antitrypsin (A1AT) abnormality based on low serum concentration are routinely confirmed through polymeras... M Owen,R Carrell,S Brennan - 《Biochimica Et Biophysica Acta》 被引量: 0发...
Alpha-1 antitrypsin deficiency (AATD) is a genetic condition characterized by low serum levels of the protein alpha-1 antitrypsin. Because there are no unique clinical symptoms that point to a definitive diagnosis of AATD, laboratory testing is crucial to differentiate this disease from others.To ...