The stomata apertures in all of the mutant lines did not respond to darkness or challenge with Pst DC3000. The WRKY22 and WRKY25 proteins both localize in the nucleus, but we found no evidence of a physical interaction between them. The WRKY22 TF was found to be involved in the ...
nuclear translocation of the NF-κB p65 subunit together with increased expression of NF-κB–mediated proinflammatory cytokines. A20 restricts NF-κB signals via its deubiquitinase activity. In cells expressing mutant A20 protein, there is defective removal of Lys63-linked ubiquitin from TRAF6, NEMO ...
A20 is a potent inhibitor of the NFκB signaling pathway3.TNFAIP3mutant truncated proteins are likely to act by haploinsufficiency since they do not exert a dominant-negative effect in overexpression experiments. Patients' cells show increased degradation of IκBα and nuclear translocation of NFκB...
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mutant V (n = 8) P < 0.001; no significant difference between WT and mutant V (P = 0.054). Means are represented as horizontal bars, s.d. as boxes, s.e.m. as whiskers and points represent individual data. b, Western blot analysis for ADCY3 and tubulin (TUB) from ...
Fruit color substantially affects consumer preferences, with darker red strawberries being economically more valuable due to their higher anthocyanin content. However, the molecular basis for the dark red coloration remains unclear. Through screening of an ethyl methanesulfonate mutant library, we identified...
To investigate whether this reduced affinity of the R288H mutant receptor could be generalized to other natural ligands, similar analyses were carried out with 9(S)-HODE and 15(S)-HETE, both of which have been reported to be natural PPARγ ligands (Nagy et al. 1998). As shown in Figure...
N-terminal H4 peptides (1-21aa) and the mutant ones H4-R3K (1-21aa) were used as substrates. Different molar ratio of PRMT5/MEP50 protein complex (calculated as tetramer) to the full length OXR1A or truncated ones, such as 4:1 ( +), 1:1(+ +), and 1:4(+ + +)...
12 If such transcripts were translated, then the mutant protein would have C-terminal truncations that lack functional SET domains (fig. 2D). The p.R1137X mutation is predicted to affect the major isoform 1 and isoform 3 but not isoform 2 of the Eu-HMTase1 protein (fig. 2D). Table ...
(b) Complementary DNA (cDNA) sequence for the wild-type and mutant alleles with corresponding protein translations. The numbers at the two sides of the sequences indicate the locations in the coding region (CDS) and protein sequences. (c) Location of the insertions in context of the known ...