Define loss-of-function mutation. loss-of-function mutation synonyms, loss-of-function mutation pronunciation, loss-of-function mutation translation, English dictionary definition of loss-of-function mutation. n. 1. The act or process of being altered or
DefinitionDefinitionIs any mutation of a gene that causes decreased or abolished function and/or activity of its encoded protein or of a protein that is directly or indirectly regulated by the mutatedGoldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M, Fraser R, Young C...
Gain-of-function mutation:A mutation that confers new or enhanced activity on a protein. Loss-of-function mutations, which are more common, result in reduced or abolished protein function. Loss of function and gain of function mutation | oncogenes and tumor suppressor genes 37 related questions ...
Loss-of-function loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-head gage Loss-of-Income Loss-of-income insurance Loss-Of-Load-Probability Loss-of-Lock Reset Enable Loss-Of-Pumping Accident Loss-Of-Pumping...
loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-function mutation loss-of-head gage Loss-of-Income Loss-of-income insurance Loss-Of-Load-Probability Loss-of-Lock Reset Enable Loss-Of-Pumping Accident Loss-Of-Pumping Incident Loss-of...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
However, the consequences on cognition of a chronic alteration in Tph2 enzymatic activity resulting from loss of function mutations have remained unexplored. The R439H Tph2-KI mice carry a rare coding single point mutation (SNP) identified in a cohort of humans with major depression as well as...
Investigating if the new p53 variant is a gain-of-function mutation using tumor cells To investigate the possibility that the new p53 variant was a gain-of-function mutation, we stably expressed it in H1299 (p53 null) cell lines to examine p21 gene and protein expression using DNA-damaging ...
compared to the soft-core genes (Fig.1band Supplementary Table3). These results may reflect the lower effective population size of the PAVs (reducing the efficiency of purifying selection) and the higher fitness gain from purging genes that have accumulated non-synonymous (loss-of-function) ...
Inactivation of PTEN by deletion or mutation is identified in ∼20% of primary prostate tumour samples at radical prostatectomy and in as many as 50% of castration-resistant tumours. Loss of phosphatase and tensin homologue (PTEN) function leads to activation of the PI3K–AKT (phosphoinositide ...