... gain-of-function mutant 突变体 gain-of-function dominant 功能放大显性 ... dict.youdao.com|基于3个网页 2. 获得功能突变体 这种方法对隐性突变体是相当直接的方法,但对于显性或半显性遗传的获得功能突变体(gain-of-function mutant)却存在问题。后…liu3305602.blog.163.com|基于1 个网页 3. 取得...
gain of function mutant 功能突变体的获得 例句：1.Central nervous system hyperexcitability associated with glutamate dehydrogenasegain of function mutations 中枢神经系统兴奋性过高与谷氨酸脱氢酶获得性功能突变 2.Five IGFBP 3 mutants were generated after DNA sequence analysis, then theinteractions ...
Gain-of-function (GOF) mutant p53 has been shown to transactivate a number of genes that are part of cell growth and survival pathways and cause an increase in tumourigenicity. Knockin and transgenic mouse models have been utilised to explore the GOF phenotype of mutant p53. Currently, p53 ...
Twitter Google Share on Facebook (redirected fromgain-of-function mutation) Thesaurus Medical Legal Encyclopedia Related to gain-of-function mutation:back mutation,genetic mutation,gene mutation,conditional mutant mu·ta·tion (myo͞o-tā′shən) ...
in the nucleotide sequence of a single gene, it is referred to as gene mutation; when it involves the structures or number of the chromosomes, it is referred to as chromosome mutation, or rearrangement. Mutations may be recognizable by their effects on the phenotype of the organism (mutant)....
Systematic analysis of deletion mutant alleles, both individually and in combination, have made an enormous impact on gene function discovery. However, while loss-of-function genetic analyses identify functionally coherent gene modules and the connections between them, they are not always sufficient for...
We report that the expression of murine or human mutant p53 proteins in cells with no endogenous p53 proteins confers new or additional phenotypes upon these cells. Mutant p53 proteins expressed in cell lines lacking p53 resulted in either enhanced tumor
All 3 mutant proteins appear to form an altered complex with ssDNA. Each saturates dT30 ssDNA at a lower stoichiometry than wild type: the binding ratio was 2.2 for RPAWT, 1.3 for RPAV227A, 1.1 for RPAE240K, and 1.6 for RPAT270A (Figure 2B; supplemental Table 3). We next examined...
Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis. Abstract Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion...
2) shb1-L loss-of-function mutant shb1-L功能缺失突变体3) gain-of-function mutation 功能获得突变 1. Comparing with clas-sical T-DNA knock-out mutagenesis technology by the loss-of-function mutation, the activation T-DNA tagging technique based on the gain-of-function mutation has its ...