... gain-of-function mutant 突变体 gain-of-function dominant 功能放大显性 ... dict.youdao.com|基于3个网页 2. 获得功能突变体 这种方法对隐性突变体是相当直接的方法,但对于显性或半显性遗传的获得功能突变体(gain-of-function mutant)却存在问题。后…liu3305602.blog.163.com|基于1 个网页 3. 取得...
gain of function mutant 功能突变体的获得 例句：1.Central nervous system hyperexcitability associated with glutamate dehydrogenasegain of function mutations 中枢神经系统兴奋性过高与谷氨酸脱氢酶获得性功能突变 2.Five IGFBP 3 mutants were generated after DNA sequence analysis, then theinteractions ...
Twitter Google Share on Facebook (redirected fromgain-of-function mutation) Thesaurus Medical Legal Encyclopedia Related to gain-of-function mutation:back mutation,genetic mutation,gene mutation,conditional mutant mu·ta·tion (myo͞o-tā′shən) ...
Gain-of-function (GOF) mutant p53 has been shown to transactivate a number of genes that are part of cell growth and survival pathways and cause an increase in tumourigenicity. Knockin and transgenic mouse models have been utilised to explore the GOF phenotype of mutant p53. Currently, p53 ...
in the nucleotide sequence of a single gene, it is referred to as gene mutation; when it involves the structures or number of the chromosomes, it is referred to as chromosome mutation, or rearrangement. Mutations may be recognizable by their effects on the phenotype of the organism (mutant)....
We report that the expression of murine or human mutant p53 proteins in cells with no endogenous p53 proteins confers new or additional phenotypes upon these cells. Mutant p53 proteins expressed in cell lines lacking p53 resulted in either enhanced tumor
MichaelCostanzo, ...CharlesBoone, inHandbook of Systems Biology, 2013 Gain-of-Function Alleles Systematic analysis of deletion mutant alleles, both individually and in combination, have made an enormous impact on gene function discovery. However, while loss-of-function genetic analyses identify function...
and p53 mutant-positive PCa cell growth in vitro and in mice. Our study identifies a gene transactivation function of GOF mutant p53 and reveals β-Catenin as a transcriptional target gene of p53 GOF mutants and a driver and therapeutic target of TMPRSS2-ERG- and p53 GOF mutant-positive ...
The mutant protein had no in vitro signal transduction activity; however, cells co-expressing the mutant and wild-type PROKR2 exhibited markedly exaggerated ligand-induced Ca2+ responses. The results indicate that certain inactive PROKR2 mutants can cause early puberty by enhancing the functional ...
Here we define a novel gain-of-function of mutant p53 (mutp53), whereby mutp53-overexpressing cancer cells acquire superior tolerance to proteotoxic stress. mutp53 via constitutive stimulation of EGFR and ErbB2 signaling hyperactivates the MAPK and PI3K cascades, which induce stabilization and ...