doi:10.1016/S0895-7061(97)89489-7RyuichiMorishitaandToshioOgiharaSDOSAmerican Journal of Hypertension
In our present study, a reverse genetic strategy such as that for ZmPLD3 represented a novel approach to expand genetic resources for the potential of breeding super haploid inducers. Further studies on pollen-specific DEGs involved in HI will not only contribute to elucidating the molecular netwo...
Although all LOF methods reduce gene activity, the choice of approach (for example, mutagenesis, CRISPR-based gene editing, RNA interference, morpholinos or pharmacological inhibition) can have a major effect on phenotypic outcomes. Interpretation of the LOF phenotype must take into account the ...
First, our approach naively treats genes with no pLoFs observed as having P = 0, even though pLoFs might be discovered at a larger sample size. Second, we naively group all populations together, even though the distribution of populations sampled in gnomAD does not reflect the world ...
Within the same approach, we find that hadronic observables show a much lesser sensitivity to these aspects. We conclude that electromagnetic observables allow access to dynamical regions that are beyond the reach of soft hadronic probes.View full text...
However, we believe that we have demonstrated the utility of our approach, which will improve with larger datasets. Additionally, whilst none of the individuals in UKB carrying pLoFs in the genes highlighted have been diagnosed with any of the conditions in question, there may be relevant ...
Here, we applied a PCR-based, multiplex identifier-tagged deep sequencing approach to screen 404 uORF translation initiation sites of 83 human tyrosine kinases and 49 other proto-oncogenes in 308 human malignancies. We identified loss-of-function uORF mutations inEPHB1in two samples derived from ...
P-values we calculated using the same bootstrapping approach but for each permutation MAPS was calculated for each of the two variant sets of interest, A and B. The P-value was defined as the proportion of permutations where MAPS of B was less than MAPS of A. ...
In this study, we have addressed the consequences of SETD2 loss-of-function through an integrated bioinformatics and functional genomics approach. We find that bi-allelic SETD2 aberrations are not associated with microsatellite instability in ccRCC. SETD2 depletion in ccRCC cells revealed aberrant ...
A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation. A genome-wide analysis demonstrates that antigens for approximately 80% of the human protein-coding genes can be selected with this strategy.doi:10.1002/... L Berglund,E Bjã¶Rling,K Jonasson,...