Gain- and loss-of-function approaches in the chick embryo.The chicken embryo has been used as a classical embryological model for studying developmental events because of its ready availability, similarity to the human embryos, and amenability to embryological and surgical manipulations. With the ...
Gain‐ and Loss‐of‐Function Approaches in the Chick Embryo The chicken embryo has been used as a classical embryological model for studying developmental events because of its ready availability, similarity to the ... Sauka‐SpenglerT,BarembaumM 被引量: 156发表: 2008年 Specific Gain- and Los...
We study the stochastic dynamics of the two most common patterns in cancer initiation and progression: loss-of-function and gain-of-function mutations. We consider three stochastic models of cell populations with a constant size: a mass-action model, a spatial model and a hierarchical model. For...
gain-of-function是什么意思 网络 功能获得性; 功能获得; 获得功能; 功能获得突变; 获得性功能; [例句]Then loss-and gain-of-function approaches were used to establish a direct role of ... gain-of-function是什么意思 网络 功能获得性; 功能获得; 获得功能; 功能获得突变; 获得性功能; [例句]Then lo...
Based on their effect on protein function, variants can be categorized into two main types: gain-of-function (GOF) variants, which enhance the activity of the mutated protein, and loss-of-function (LOF) variants, which cause partial or complete protein inactivation.1 Over the past decades, ...
Distinct members of the large ethylene response factor (ERF) family, namely ERF96 and the six highly related subgroup IXb members ERF102 to ERF107, were identified. Whereas overexpression of these ERF significantly reduces fungal propagation, single loss-of-function approaches did not reveal altered...
Chlamydiae is a bacterial phylum composed of obligate animal and protist endosymbionts. However, other members of the Planctomycetes–Verrucomicrobia–Chlamydiae superphylum are primarily free living. How Chlamydiae transitioned to an endosymbiotic lifes
Current computational approaches evaluating loss-of-function in genes carrying these variants rely on gene-level characteristics such as evolutionary conservation and functional redundancy across the genome. However, innate immunity genes represent a particular case because they are more likely to be under...
Overexpression of miR156 reduces the plas- tochron length by suppressing SPL genes that delay juvenile-to-adult phase transition. Several reports have described loss-of-function mutants isolated from the nDart1-promoted tagging line. Herein, we report a gain-of-function mutant designated Bushy ...
Actual link calculation includes other effects such as attenuation in atmosphere, rain attenuation, antenna tracking errors, losses associated with transmitting and receiving antennas, etc. Figure 13 shows the free-space path loss at different satellite orbits and frequencies. At typical altitudes of 100...