Fischbach, 2005.Loss- and gain- of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development. Mol Cell Neurosci. 30(3): p. 326-38....
Studies conducted in our laboratory have demonstrated that activated immune cells produce a soluble inhibitor(s) of cardiac myocyte contractile and cyclic ... MK Chung,TS Gulick,RE Rotondo,... - 《Circulation Research》 被引量: 350发表: 1990年 Heterodimerization of beta1- and beta2-adrenergic ...
Related to Gain of function:genetic mutation,mutation,Conditional mutation,Loss of function mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
and Barembaum, M. (2008). Chapter 12 gain- and loss-of- function approaches in the chick embryo. Methods Cell Biol. 87, 237-256.Sauka-Spengler, T., & Barembaum, M. (2008). Chapter 12 Gain- and Loss-of-Function Approaches in the Chick Embryo. Methods in Cell Biology, 237-256....
Summary. Background: A large number of clinical studies have documented that a loss-of-function variant CYP2C19*2 affects clinical profiles of clopidogrel (efficacy and safety). However, data on the impact of a gain-of-function variant CYP2C19*17 on the response to that drug seem to be less...
We also found that loss of a single copy of Dnd1 in Dnd1KO/+ heterozygotes did not affect baseline occurrence of TGCT-affected males and that Dnd1Ter increased TGCT risk regardless whether the alternative allele was loss-of-function (Dnd1KO) or wild-type (Dnd1+). Finally, we found ...
(redirected fromgain-of-function mutation) Dictionary Thesaurus Medical Legal 1.the act or process of mutating; change; alteration 2.a change in the chromosomes or genes of a cell. When this change occurs in the gametes the structure and development of the resultant offspring may be affected ...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...
The debate on whether to allow experiments that increase the transmission and/or pathogenicity of potential pandemic pathogens has recently gained renewed attention, particularly as a result of studies on influenza viruses. Here, five experts discuss the
Loss-of-function mutations could also have an impact on pathogenesis. For example,in vitrostudies of a HAdV-C5 E1B-19K gene deletion mutant was associated with enhanced proinflammatory responses by activated macrophages compared with wild-type HAdV-C5 infection [37]. This suggests that E1B-19K...