Long-term potentiation (LTP) is a form of synaptic plasticity, which can be elicited by a short chain of electrical pulses (50–100 Hz stimulation for 1-2 sec at moderate intensity). Because of the long duration of the LTP and the near physiological properties of the stimulation required to...
long‐term potentiationsynaptic plasticityA Hebbian form of long‐term potentiation (LTP) is believed to be the basis of memory storage at CA3 recurrent synapses. Abnormalities in CA3 intrinsic connectivity have been related to memory deficits in a variety of neurological disorders. Despite the ...
Pharmacological studies of long-term potentiation (LTP) in the hippocampus are starting to provide a molecular understanding of synaptic plastic processes which are believed to be important for learning and memory in vertebrates. In the CA1 region of the hippocampus, the synaptic activation of ...
Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation. LTP has be... MT Rogan,UV Stäubli,JE Ledoux - 《Nature》 被引量: 2298发表: 1997年 Fear conditioning induces associative long-term potentiation in the...
In new work, we compare STP with a rebound potentiation (RP) that is induced by NMDA application and conclude that they are different phenomena. We also report that NMDAR dependent long-term depression (NMDAR-LTD) is sensitive to a glycine site NMDAR antagonist. We conclude that NMDARs are ...
The late stage of long-term potentiation (LTP) and long-term memory is believed to be largely governed by altered gene expression for its generation and maintenance, while the early stages of LTP and memory are controlled mainly by the phosphorylation-dephosphorylation of the synaptic proteins. For...
Memory is believed to occur in the human brain as a result of two types of synaptic plasticity: short-term plasticity (STP) and long-term potentiation (LTP; refs1,2,3,4). In neuromorphic engineering5,6, emulation of known neural behaviour has proven to be difficult to implement in softwar...
Long-Term PotentiationMemoryNerve Tissue Proteins细胞支架蛋白质类海马长时程增强记忆神经组织蛋白质类It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In experimental models of synaptic plasticity, such as long-...
Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fund... SN Davies,RAJ Lester,KG Reymann,... - 《Nature》 被引量: 824发表: 1989年 Long-term potentiation and kindling: How similar are the...
isbyan HippocampalLong-TermPotentiationIsChronicOpiateTreatmentRe·-ExposuretoOpiatesandCanBeReducedbyRestoredbyLuPu,’。Guo-BinBao,1Nan—JieXu,’LanMa,andGangPei’1LaboratoryofMolecularCellBiology,InstituteofBiochemistryandceHBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences,Shangh~200031,...