Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. J. Neurosci. 26, 1128–1132 (2006). Article CAS PubMed PubMed Central Google Scholar ...
Long-term potentiation (LTP) describes the long-lasting increase in the strength of synaptic transmission between two neurons, a process that may be integral to learning and memory. In this Review, Lisman and colleagues examine the central role that calc
Demonstrates that the re-expression of the brain-derived neurotrophic factor (BDNF) gene in the CA1 region almost completely restores the severely impaired long-term potentiation in hippocampal sites of BDNF-deficient mice. Evaluation of the relationship between the absence of a particular gene and ...
havebeenimplicatedinvariousneuronalfunctionsandinthepathogenesisofAlzheimer’sdisease.IthasbeenreportedthatinductionoftPAexpressionmaycontributetoactivity-dependentsynapticplasticityinthehippocampusandcerebellum.Inaddition,long-termpotentiation(LTP)issignificantlydecreasedinmicelackingtPA.Herewedemon-stratethattPAreceptor...
Together these results imply that the potentiation of AMPAR responses is dependent upon an NMDAR-mediated rise in [Ca2+]i. At first glance, these observations might appear contrary to the concept that NMDARs are said to be “blocked” at the resting membrane potential by Mg2+. However, even...
Fig. 3A demonstrates that larger enhancement of proximal fEPSP (electrode 4) was recorded in the absence of a strong population spike (electrode 5) able to invade apical dendrites. Nonetheless, since amplitudes of population spikes are known to undergo much stronger potentiation compared to fEPSPs...
Cerebellar long-term potentiation under suppressed postsynaptic Ca2+ activity Neuroreport, 3 (1992), pp. 231-234 Google Scholar 60 R Shigemoto, T Abe, S Nomura, S Nakanishi, T Hirano Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells...
Long-term potentiation, a cellular correlate of memory, was still achievable, magnetic resonance spectroscopy revealed no major changes in metabolites, and diffusion tensor imaging revealed normal microstructure and tissue integrity in the hippocampus. More specifically, all measures of diffusion appeared ...
Pedosiaittievsetastteims fuolri that lead to increasing conductance represent excitatory actions, and the following negative stimuli represent inhibitions. Achievement of the input-dependent enhancement of synaptic weight is of popular interest, such as post-tetanic-potentiation (PTP), short-term memory...
Growing evidence indicates that HDACs are powerful modulators of long-term potentiation (LTP) as well as memory formation14,15,16. Increased histone-tail acetylation facilitates various types of long-term memories, including hippocampus-dependent contextual fear conditioning and spatial memory17,18,19,...