Long-term potentiation (LTP) is a neurobiological mechanism of cognitive function, and the N-methyl-D-aspartate (NMDA) receptors is fundamental for LTP. Previous studies showed that over activation of NMDA receptors may be a crucial cause of LTP and cognitive impairment induced by stress or ...
Long-term potentiation (LTP) describes the long-lasting increase in the strength of synaptic transmission between two neurons, a process that may be integral to learning and memory. In this Review, Lisman and colleagues examine the central role that calc
The thalamo-amygdala pathway also exhibits long-term potentiation, a form of synaptic plasticity that might underlie the emotional learning functions of the ... JE Ledoux - 《Behavioural Brain Research》 被引量: 1557发表: 1993年 Prefrontal Mechanisms in Extinction of Conditioned Fear Amygdalainfralimb...
Thus this initial characterization of late-LTP demonstrates that isolating the dendrites of CA1 pyramidal neurones does not prevent the ability to induce a long-lasting potentiation of synaptic transmission. Furthermore, the late-LTP observed shares several of the fundamental properties of late-LTP se...
Growing evidence indicates that HDACs are powerful modulators of long-term potentiation (LTP) as well as memory formation14–16. Increased histone-tail acetylation facilitates various types of long-term memories, including hippocampus-dependent 1Department of Functional region of Diagnosis, Hebei Medical...
A new study demonstrates that postsynaptic neurons alone can express long... Robert,Malenka,Roger,... - 《Nature Neuroscience》 被引量: 7发表: 1998年 Demonstration of Unsupervised Learning With Spike-Timing-Dependent Plasticity Using a TFT-Type NOR Flash Memory Array The long-term potentiation (...
Soluble TREM2 species inhibit long-term potentiation (LTP). Electrophysiology analysis of LTP in C57BL/6J mice brain slices incubated with soluble TREM2 species at 15 ng/ml. A–C Incubations with sTREM2H157, sTREM2222, and sTREM2219, respectively. For each isoform, a time course with the ...
beenreportedthatinductionoftPAexpressionmaycontribute toactivity-dependentsynapticplasticityinthehippocampus andcerebellum.Inaddition,long-termpotentiation(LTP)is significantlydecreasedinmicelackingtPA.Herewedemon- stratethattPAreceptorLRPisabundantlyexpressedinhip- ...
Growing evidence indicates that HDACs are powerful modulators of long-term potentiation (LTP) as well as memory formation14,15,16. Increased histone-tail acetylation facilitates various types of long-term memories, including hippocampus-dependent contextual fear conditioning and spatial memory17,18,19,...
In the past few years, PKMζ has been found to be critical for the maintenance of long-term potentiation (LTP) and long-term memories (Pastalkova et al, 2006; Sacktor 2008). Microinfusion of the PKCζ inhibitory peptide ZIP abolished the maintenance of various types of long-term memories...