To assess if mild BA.2 BTIs have long-term effects on the hematopoietic system, we analyzed the levels of red blood cells (RBCs), platelets (PLTs) and white blood cells, which are critical for host immune defense, antigen clearance and wound healing (Fig.1d). Large numbers of small RBCs...
Long-Term Enzymatic and Phenotypic Correction in the Phenylketonuria Mouse Model by Adeno-Associated Virus Vector-Mediated Gene Transfer HYUN-JEONG OH, EUN-SOOK PARK, SEONGMAN KANG, INHO JO, AND SUNG-CHUL JUNG Department of Biomedical Sciences, National Institute of Health, Seoul 122–701, Korea...
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief p
Since the discovery and classification of non-coding RNAs, their roles have gained great attention. In this respect, microRNAs and long non-coding RNAs hav
All but one of the fractures occurred 3-5 yr after beginning therapy, in spite of the well-known early drop of BMC in the first months of coiticosteroid therapy. Four drug-related drop-outs due to side-effects were reported in the PDN group, all more than 2 yr after beginning therapy...
University of Groningen SIRT 1 Polymorphism , Long-Term Survival and Glucose Tolerance in the General Population 来自 Semantic Scholar 喜欢 0 阅读量: 7 作者:S Figarska,J Vonk,H Boezen 摘要: Mutations that increase activity of Sir2 (silent information regulator 2) are associated with extended ...
In a similar fashion, co-administration of 2-DG with other anticancer drugs demonstrated potential anticancer benefits in preclinical models [50]. However, it has been observed that 2-DG has minor effects as a single agent for antiglycolytic therapy, owing to the drug's non-selectivity, which...
Here, we show that TGFβ signaling represses LINC00707 expression via specific transcriptional mechanisms, and LINC00707 forms complexes with Smads and limits TGFβ signaling based on cytoplasmic retention of Smads. Thus, long-term suppression of LINC00707 expression by TGFβ enhances pro-tumorigenic ...
The Importance of the Mean Platelet Aggregation Degree in Long-term Dual Antiplatelet Therapy Following Drug-Eluting Stent Implantationdoi:10.1111/1755-5922.12177ClopidogrelCoronary artery diseaseDual antiplatelet therapyPrognosisJohn Wiley & Sons, LtdCardiovascular Therapeutics...
The IDEAL framework provides a structured evaluation pathway for surgical innovation and devices, from needs analysis and preclinical testing, to long-term studies of widespread use9,14,15(Fig.1). However, the breadth of the evaluation problem of surgical robotics goes beyond both IDEAL and the ...