The drug is known to increase cardiac output by exerting inotropic and chronotropic effects on the heart. Additionally, it has a vasodilatory effect via downregulation of pMLC2 downstream of PKA, and vasoconstrictive effect that is exerted via α-AR signaling19. All three types of β-ARs, ...
That is, the acute effect of GRK2 inhibitors short-term may improve diabetic metabolism by improving peripheral tissue glucose utilization; although the impact on non-diabetic animals was not investigated. Thus, understanding the role of GRK2 in metabolically-demanding and metabolite-sensing organs is...
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Cannabis is one of the most commonly elicited substances abused. It is easily accessible, inexpensive, and the ultimate gateway drug. Synthetic cannabinoid has been known to be packaged under numerous trade names such as "K2, spice, AK-47, Geeked up, Smacked, and Green Giant..etc". K2 Abu...
We hypothesized that increased Flt-1+ macrophages may stimulate endothelial cell behavior, with resulting effects on vascularization. HUVEC tube formation assays were performed to assess this possibility. As compared to co-cultured Raw264.7 cells, VEGF-treated Raw264.7 cells increased the ability of ...
Regulatory effects of GRK2 on GPCRs and possible use as a drug target G protein-coupled receptor kinase 2(GRK2),as a key Ser/Thr protein kinase,belong to the member of the G protein-coupled receptor kinase(GRK)family.The C-te... Chen-chen,Yang,Yi-fan,... - 《中国药理学与毒理学杂...
The term “immunogenicity” as used herein, is the ability of a particular substance, such as an antigen or epitope, to provoke an immune response in the body of a mammal. This immune response could be humoral and/or cell-mediated. The term “activation”, as used herein, refers to the...
Differential drug effects on spontaneous and evoked pain behavior in a model of trigeminal neuropathic pain J. Pain Res., 10 (2017), pp. 279-286, 10.2147/jpr.s124526 View in ScopusGoogle Scholar [38] T. Nishinaka, M. Kinoshita, K. Nakamoto, S. Tokuyama Sex differences in depression-like...
A summary of the mouse lines generated can be found in Supplementary Role of GRK2 in the brain dopamine system TL Daigle et al Table S1. Drug and experiment-naive adult mice (2–6 months of age) and of mixed sex were used for all studies. Animals were placed on a 12-h light/dark...
which led to seizure-related death (Fig.8c, d), suggesting that retigabine has no long-lasting effects. Retigabine, however, did not rescue the hyperactivity or anxiety-like behavior of Ank2-cKO mice in the open-field test and had no effect on the body weight (Fig.8e–g; Supplementary...