Long Non-Coding RNA Sequencing Introduction Long non-coding RNAs (lncRNAs) are thought to encompass nearly 30,000 different transcripts in humans, hence lncRNA transcripts account for the major part of the non-coding transcriptome. lncRNA discovery is still at an early stage and only a small pr...
近日,哈佛大学、麻省总医院朱肇中团队采用RNA转录组学(RNA sequencing)研究方法,发现在患重症细支气管炎的婴儿中,其鼻咽部气道内的一些long non-coding RNA(lncRNA)的变化与呼吸道病毒感染、儿童哮喘的风险因素和lncRNA调控的表观遗传学...
Long noncoding RNAs: fresh perspectives into the RNA worldLong noncoding RNAnext-generation sequencingepigeneticstherapeuticsLarge-scale mapping of transcriptomes has revealed significant levels of transcriptional activity within both unannotated and annotated regions of the genome. Interestingly, many of the ...
《Long Non-Coding RNA Biology》是一本由M.R.S. Rao著的专业书籍,该书于2017年由Springer出版社出版。原著中说明了可以用于交流学习,不涉及商业用途就可以,因此不存在侵权问题。 本书是关于长非编码RNA(lncRNA)的综合性教材,涵盖了lncRNA的多个方面,包括结构、功能、调节机制、疾病相关性等等。该书共分为10章...
With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-coding signaling pathways underlie various biologi...
名词解释长非编码 RNA(long non-coding RNA,IncRNA) 答案 长非编码RNA:是一类长度为200~100000个核苷酸的RNA分子。lncRNA由RNA聚合酶Ⅱ转录生成,经剪切加工后,形成具有类似于mRNA的结构。lncRNA有poly(A)尾和启动子,但序列中不存在可读框,不编码任何蛋白质。lncRNA具有调控的多样性,可从染色质重塑、转录调控及转...
(Next Generation Sequencing,NGS)技术对肝细胞癌(hepatocellular carcinoma,HCC)患者活检标本及正常对照肝组织样品进行高通量RNA测序(RNA-Sequencing,RNA-Seq),在肝癌样品中染色体11q13.1区域检测到几个相邻的RNA-Seq信号峰,而在正常对照组织中没有检测到,且该染色体区域目前尚无已知基因登录,提示这几个RNA-Seq峰可能...
长链非编码RNA(long noncoding RNA, lncRNA)指的是长度超过200nt的RNA分子。它们不编码蛋白,位于细胞核或胞质内,具有保守的二级结构,可与蛋白质、DNA和RNA相互作用,通过多种机制(如基因印记、染色质重塑、细胞周期调控、剪接调控、mRNA降解和翻译调控等)在多种层面上(如表观遗传学、转录调控及转录后调控等)调控...
长非编码RNA(long non-coding RNAs)是一类长度大于200 nt的非编码RNA。已有研究表明,长非编码RNA具有重要的调控功能,在植物和动物的生物学过程中发挥重要作用。最近,中科院生物物理所等发布新的非编码RNA整合资源NONCODEV6数据库。°生物物理所等发布新的非编码RNA整合资源NONCO... ...
Previous studies have suggested that >90% of multi-exonic protein-coding genes can be alternatively spliced, giving rise to distinct isoforms across different temporal stages39. Using our deep RNA sequencing data regardingS. scrofalncRNAs and protein-coding genes in postnatal skeletal muscle, we ident...