A 60-mg loading dose of prasugrel achieves greater platelet inhibition than 300-mg and 600-mg loading doses of clopidogrelBackground Prasugrel (Pras), a novel thienopyridine, is being compared with clopidogrel (Clop) in patients with ACS in TRITON-TIMI 38. Recent studies have shown greater ...
Patientsrandomlyassignedto receive prasugrel received a 60-mgloadingdosebeforetheprocedure,followedby10 mgdaily. 病人被随机安排给予普拉格雷,术前60mg负载量,之后每天10mg。 news.dxy.cn 4. A lotofcentersarealreadyusingthehigherloadingdose. 很多中心已经在使用更高的负荷剂量。
: the TRIPLET trial Transferring from clopidogrel loading dose to prasugrel loading dose in ACS patients: the TRIPLET trialTransferring from clopidogrel loading dose to prasugrel loading dose in ACS patients: the TRIPLET trialJ. Diodati
Diodati J G, Saucedo J F, Cardillo T E, et al. Transferring from clopidogrel loading dose to prasugrel loading dose in acute coronary syndrome patients.High on-treatment plate- let reactivity analysis of the TRIPLET trial [ J ]. Thromb Haemost, 2014,112 (2) : 311 - 322....
Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Th... Dual antiplatelet therapy with aspirin and clopidogrel is standard for prevention of thrombotic complications of percutaneous coronary intervention (...
prasugrel administration in patients with myocardial infarction undergoing coronary stenting: the FABOLUS PRO (Facilitation through Aggrastat By drOpping or shortening Infusion Line in patients with ST-segment elevation myocardial infarction compared to or on top of PRasugrel given at loading dOse) trial....
alternative to pre-treatment given several hours before diagnostic angiography or PCI.Still there is concern about adequate platelet inhibition, which can be overcome either with new loading scenarios or introducing more potent, more predictable, faster onset antiplatelet drugs, such asprasugrel and ...
A dose-response effect across the three LDs was found for IPA using 20 μmol/l ADP and inhibition of platelet activation. Compared with a standard 300-mg LD, a 900-mg LD provides greater platelet inhibition within 1 h, an effect that persisted for at least 24 h. In addition, there ...
for STEMI: oral administration of prasugrel alone at a loading dose of 60 mg or the administration of tirofiban 25 μg/kg bolus with or without a 0.15 μg/kg/min 2-h post-bolus infusion of tirofiban with concomitant or post-infusion administration of either 60 mg of prasugrel or 600 ...
Comparison of double (360 mg) ticagrelor loading dose with standard (60 mg) prasugrel loading dose in ST-elevation myocardial infarction patients: The Rapi... In ST-elevation myocardial infarction (STEMI) patients, residual platelet reactivity soon after a loading dose (LD) of prasugrel or ticagre...