比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μL, 一共给药动物 10 只 ,您使用的配方为 5% DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL。 母液配置方法: 2 mg 药物溶于 50 μLDMSO( 母液浓度为 40 mg/mL), 如您需要配置的浓度超过该...
Cost-Effectiveness of Prasugrel Versus Clopidogrel in Patients With Acute Coronary Syndromes and Planned Percutaneous Coronary Intervention BACKGROUND: In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcom......
in elective percutaneous coronary intervention (PCI) or non–ST-segment elevation acute coronary syndrome (NSTE-ACS), showing no significant effect on mortality and a trend toward a decrease of ischemic endpoints but at the cost of an increase of major bleeding 1, 2, 3, 4, 5, 6, 7, 8....
(LD60/MD10 mg)(LD30/MD7.5 mg)(LD30/MD5 mg) N(Males) 12(5) 12(7) 12(7) Age, yearsmean ± SD 36.3 ± 3.7 34.0 ± 3.9 34.8 ± 3.6 Weight, kgmean ± SD 57.8 ± 4.9 59.8 ± 6.6 60.8 ± 6.3 BMI, kg/m2mean ± SD 22...
Globally, however, the standard dose of prasugrel is likely to be more efficient than a standard dose of clopidogrel at the cost of safety, as reported in the TRITON-TIMI38 [6]. One of the largest network meta-analyses involving 52,816 patients from 12 randomized trials showed that ...