比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μL, 一共给药动物 10 只 ,您使用的配方为 5% DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL。 母液配置方法: 2 mg 药物溶于 50 μLDMSO( 母液浓度为 40 mg/mL), 如您需要配置的浓度超过该...
On July 10, 2009, the US Food and Drug Administration approved the use of prasugrel for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI. Prasugrel is a member of the thienopyridine class of ...
Incremental cost for the first year was 0.32 (US$0.50, €0.40) with clopidogrel 600mg, 608 (US$977, €709) with prasugrel and 665 (US$1068, €775) with ticagrelor. All three strategies have shown a similar reduction in MACE at 30days by comparison to clopidogrel 300mg. All three ...
(LD60/MD10 mg)(LD30/MD7.5 mg)(LD30/MD5 mg) N(Males) 12(5) 12(7) 12(7) Age, yearsmean ± SD 36.3 ± 3.7 34.0 ± 3.9 34.8 ± 3.6 Weight, kgmean ± SD 57.8 ± 4.9 59.8 ± 6.6 60.8 ± 6.3 BMI, kg/m2mean ± SD 22...
Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from t... BACKGROUND: In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Ou...
Globally, however, the standard dose of prasugrel is likely to be more efficient than a standard dose of clopidogrel at the cost of safety, as reported in the TRITON-TIMI38 [6]. One of the largest network meta-analyses involving 52,816 patients from 12 randomized trials showed that ...