Fig. 1: LNP-RNA-engineered adipose stem cell therapy to treat acute diabetic wounds. a Illustration of LNP-engineered ASCs with enhanced protein-generating ability for diabetic wound healing. This illustration was created with BioRender.com and permitted for publication. b A representative synthetic ...
Co-delivery of self-amplifying RNA (saRNA) and E3 mRNA complex (the combination of saRNA and E3 mRNA is named SEC) using DIM1T LNP modulates host immune responses against saRNAs and facilitates the durable production of proteins of interest in ASCs. The DIM1T LNP-SEC engineered ASCs (DS-...