MRI-determined liver proton density fat fraction,with MRS validation:comparison of regions of interest sampling methods in patients with type 2diabetes. Vu KN,Gilbert G,Chalut M,et al. Journal of Magnetic Resonance Imaging . 2016Vu KN,Gilbert G,Chalut M,et al.MRI-determined liver proton ...
PurposeTo assess the agreement between published magnetic resonance imaging (MRI)-based regions of interest (ROI) sampling methods using liver mean proton density fat fraction (PDFF) as the reference standard. Materials and MethodsThis retrospective, internal review board-approved study was conducted in...
they are nonspecific and poor predictors of progression22,23,24. Magnetic resonance imaging (MRI)-derived proton density fat fraction (PDFF) provides accurate liver fat quantification, but liver biopsy is essential for NASH diagnosis and staging. However, biopsy involves sampling variability...
The aim of this meta-analysis was to evaluate the diagnostic accuracy of hepatic magnetic resonance imaging-proton density fat fraction (MRI-PDFF) for the assessment of liver steatosis (LS) with histology as reference standard.A systematic literature search was performed to identify pertinent studies...
磁共振技术质子密度脂肪分数 (magnetic resonance imaging-derived proton density fat fraction, MRI-PDFF)的诊断准确性可能更高,已用于临床试验评估肝脏脂肪含量及其变化。另有一些基于人体学参数、病史及常用实验室指标的简单判别模型(如脂肪肝指数Fatty Liver Index, FLI)用于基于一般人群的脂肪肝流行病学研究。
“In most studies that we run these days, MRI proton density fat fraction, or PDFF, is used to measure steatosis,” Benson offers. Because fat is measured throughout the entire liver, he notes, the technique is potentially a vast improvement over liver biopsy, which looks at a small fragm...
S. et al. Agreement between magnetic resonance imaging proton density fat fraction measurements and pathologist-assigned steatosis grades of liver biopsies from adults with nonalcoholic steatohepatitis. Gastroenterology 153, 753–761 (2017). Article PubMed Google Scholar ...
(liver fat content [LFC] by MRI proton density fat fraction [MRI-PDFF]) and achieved clinically important secondary endpoints related to improvements in liver health and metabolism. HTD1801 was generally safe and well tolerated. This post-hoc analysis, focused on cT1, to be presented at the ...
MRI Magnetic resonance is the most accurate non-invasive technique for the evaluation of hepatic steatosis, because it can directly quantify the amount of liver TG through magnetic resonance spectroscopy (MRS) or magnetic resonance imaging (MRI), by quantifying the proton density fat fraction (PDFF...
secondary end points consisted of the 6-month relative (percentage) change in hepatic fat fraction by MRS, attainment of at least a 30–percentage point relative reduction in hepatic fat, and both absolute and relative changes in liver fat content by MRI proton density fat fraction (MRI-PDFF)...