MRI-determined liver proton density fat fraction,with MRS validation:comparison of regions of interest sampling methods in patients with type 2diabetes. Vu KN,Gilbert G,Chalut M,et al. Journal of Magnetic Resonance Imaging . 2016Vu KN,Gilbert G,Chalut M,et al.MRI-determined liver proton ...
PurposeTo assess the agreement between published magnetic resonance imaging (MRI)-based regions of interest (ROI) sampling methods using liver mean proton density fat fraction (PDFF) as the reference standard. Materials and MethodsThis retrospective, internal review board-approved study was conducted in...
Purpose: To evaluate the diagnostic performance of magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) for assessing hepatic steatosis in nonalcoholic fatty liver disease (NAFLD) by using centrally scored histopathologic validation as the reference standard.Materials and Methods:...
It is challenging to both diagnose and stage NAFLD. Although liver enzymes are commonly elevated, they are nonspecific and poor predictors of progression22,23,24. Magnetic resonance imaging (MRI)-derived proton density fat fraction (PDFF) provides accurate liver fat quantification, but liver biopsy ...
Both, CT and MRI (before the era of multi-echo Dixon assessment of proton density fat fraction) provide an only moderate sensitivity and specificity for NAFLD detection and graduation7. On the other hand, proton MR spectroscopy (1H-MRS) indeed measures tissue lipid content, but is mainly used...
liverMagneticresonanceimagingMeta-analysisThe aim of this meta-analysis was to evaluate the diagnostic accuracy of hepatic magnetic resonance imaging-proton density fat fraction (MRI-PDFF) for the assessment of liver steatosis (LS) with histology as reference standard.A systematic literature search was...
Advanced MRI has shown promise for the quantitative assessment of hepatic steatosis (fat content). Schwimmer and colleagues[8]evaluated the correlation and diagnostic accuracy of MRI-estimated liver proton density fat fraction (PDFF), a biomarker for hepatic steatosis, compared with the histologic stea...
non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; PC, principal components; PDFF, proton density fat fraction; OA, other allele; OR, odds ratio; ShMOLLI, shortened modified look locker inversion; SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes; WHR_BMI, waist hi...
However, Liraglutide treatment did not significantly alter the liver mean proton density fat fraction (PDFF) (p = 0.15), magnetic resonance spectroscopy-PDFF (p = 0.80), liver volume (p = 0.30), or the total liver fat index (p = 0.39).157 Semaglutide, a GLP-1 ...
(NCT03656744). Previous studies have demonstrated that achieving at least 30% relative reduction in liver fat content (LFC) as determined by magnetic resonance imaging (MRI)- proton density fat fraction (PDFF) or an improvement in fibroinflammation as determined by at least an 80 ms reduction ...