Magnetic resonance imaging–proton density fat fraction (MRI-PDFF) is an accurate, noninvasive tool for diagnosing metabolic dysfunction–associated steatotic liver disease, but its feasibility is limited in routine clinical practice. We aimed to assess the clinical utility of alternative, cost-...
Both, CT and MRI (before the era of multi-echo Dixon assessment of proton density fat fraction) provide an only moderate sensitivity and specificity for NAFLD detection and graduation7. On the other hand, proton MR spectroscopy (1H-MRS) indeed measures tissue lipid content, but is mainly used...
S. et al. Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy. Radiology 267, 767–775 (2013). PubMed Google Scholar Siddiqui, M. S. et al. Vibration-controlled transient elastography to assess fibrosis and steatosis in patients with non...
Diagnostic accuracy of hepatic proton density fat fraction measured by magnetic resonance imaging for the evaluation of liver steatosis with histology as reference standard: a meta-analysisFatty liverMagnetic resonance imagingArea under curveMeta-analysis...
In this context, the role of liver proton density fat fraction (MR-PDFF) quantification and magnetic resonance elastography (MRE) as a diagnostic tool stands out, as they are considered by both the American Gastroenterological Association (AGA) and the American Association for the Study of Liver...
The randomized, placebo-controlled phase 2 trial, which will be presented during a late-breaking session, examines the ability of GS-0976, an acetyl-CoA carboxylase inhibitor, to forestall elevated lipogenesis. The investigators will discuss the MRI proton-density fat fraction findings they used to...
Magnetic resonance imaging proton density fat fraction NAFLD: Non-alcoholic fatty liver disease NAFLD-LFS: NAFLD liver fat score NAS: NAFLD activity score NASH: Non-alcoholic steatohepatitis NFS: NAFLD fibrosis score NIT: Non-invasive test
After 12 weeks of treatment, non-alcoholic steatohepatitis (NASH) patients treated with efruxifermin plus a GLP-1R agonist saw a 65% drop from baseline in hepatic fat fraction, as measured by the non-invasive magnetic resonance imaging-proton density fat fraction. Mean...
It is challenging to both diagnose and stage NAFLD. Although liver enzymes are commonly elevated, they are nonspecific and poor predictors of progression22,23,24. Magnetic resonance imaging (MRI)-derived proton density fat fraction (PDFF) provides accurate liver fat quantification, but liver biopsy...
However, Liraglutide treatment did not significantly alter the liver mean proton density fat fraction (PDFF) (p = 0.15), magnetic resonance spectroscopy-PDFF (p = 0.80), liver volume (p = 0.30), or the total liver fat index (p = 0.39).157 Semaglutide, a GLP-1 ...