MRI, magnetic resonance imaging; MASH, metabolic dysfunction-associated steatohepatitis; MASLD, metabolic dysfunction-associated steatotic liver disease; PHLF, post-hepatectomy liver failure; PBC, primary biliary cholangitis; PSC, primary sclerosing cholangitis; RFC, random forest classifier; SLD, steatotic...
MRI, magnetic resonance imaging; MRI-PDFF, magnetic resonance imaging proton density fat fraction; MRS, magnetic resonance spectroscopy; NAFL, nonalcoholic fatty liver; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NFS, NAFLD, fibrosis score; OGTT, oral glucose tolerance...
Fatty changes are assessed by differences in chemical shifts between fat and water; that is, the difference in MR frequency between the protons in fat and water16. However, how steatohepatitis and fibrosis influence the liver fat fraction is still unknown17. Even though MR and CT techniques ...
histological analysis or by a proton density fat fraction (PDFF, providing a rough estimation of the volume fraction of fatty material in the liver) >5.6% assessed by proton magnetic res- onance spectroscopy ( 1 H-MRS) or quantitative fat/water se- lective magnetic resonance imaging (MRI)....
A study diagnosing NAFLD by MRI-estimated proton density fat fraction ≥5% found NAFLD in 65% [16] and studies using ultrasound diagnosed NAFLD in 74% [17], 57% [18] and 70% [19] of patients with type 2 diabetes. Half of patients with type 2 diabetes have NAFLD despite having normal...
Data are presented as medians (interquartile range) with spaghetti-diagrams to present individualised changes in the hepatic fat fraction. The line within each box represents the median, and the top and bottom of the box represent the 75th and 25th percentiles, respectively. The whiskers indicate...