Ehrlich Ascites carcinoma mice model for studying liver inflammation and fibrosis We have established a functional and molecular link between the development of liver inflammation and breast cancer using the EAC (Erhlich Ascites mammary ... NGS Gowda,VD Shiragannavar,SC Prabhuswamimath,... - Advanc...
Here, we summarize current knowledge on the genetic and functional importance of the chemokine network in injury and highlight their potential for intervening in the inflammation and fibrosis that drives liver disease progression. 展开 关键词: Chemokines liver fibrosis genetics leukocyte recruitment ...
The activation of THRβ is known to improve MASH by controlling fat synthesis, regulating fatty acid oxidation, cholesterol metabolism, mitochondrial function, and reducing inflammation and fibrosis. Glucagon-like peptide-1 (GLP-1) agonists, employed to treat diabetes and obesity, has been tested on...
The accumulation of extracellular matrix proteins in liver fibrosis and cirrhosis is due to different cell types which acquire a myofibroblastic phenotype - the hepatic stellate cells, located in the space of Disse, portal fibroblasts as well as myofibroblasts of the portal and pericentral areas. ...
Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a ...
Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis The liver is an organ key to myriad metabolic and immune/inflammatory function. Thus, liver diseases have a tremendous impact on quality of life and can be lethal. Liver failure is a prototype of complex disease that has defied ...
Chronic unresolved inflammation is associated with persistent hepatic injury and concurrent regeneration, leading to sequential development of fibrosis, cirrhosis, and eventually HCC. Irrespective of the intrinsic differences among various etiological factors, a common denominator at the origin of HCC is the...
The liver is the largest immune organ of the human body. Because of acute or chronic infection, liver inflammation results in necrotic hepatocyte death [111]. Persistent hepatic damage leads to progressive fibrosis, disrupted liver architecture, cirrhosis, and subsequent tumorigenesis. The identification...
N. Liver regeneration - mechanisms and models to clinical application. Nat. Rev. Gastroenterol. Hepatol. 13, 473–485 (2016). Article PubMed Google Scholar Iredale, J. P. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest....
Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks. Instead of MCDD, a methionine–choline control diet (CD) was given for the last 2 weeks to the experimental group. Fibrosis and inflammation were determined by tissue staining. Protein...