Hepatic fibrosis is a reversible wound-healing response characterized by the accumulation of extracellular matrix (ECM) or "scar;" it follows chronic, but not self-limited, liver disease. The ECM components in
Hotta N, Ayada M, Okumura A, Ishikawa T, Sato K, Oohashi T, Hijikata Y, Murayama S, Ido M, Kakumu S, 2007.Noninvasive assessment of liver disease - measurement of hepatic fibrosis using tissue strain imaging. Clin Imaging.;31(2):87-92....
The initiation, development and resolution of hepatic fibrosis are influenced by various cytokines, chemokines, damage-associated molecular patterns (DAMPs) and signaling pathways. A significant number of studies in recent years have indicated that the p
www.519liver.com 2. It would be beneficialtodisclosing a possiblemechanismofschistosomalhepaticfibrosisand therapy of thisdisease. 为进一步揭示血吸虫病肝纤维化的机制和寻找更有效的防治途径打基础。 www.fabiao.net 3. Atpresent, there isnoeffectivedrag forhepaticfibrosis, andtherapyon theetiologiesisstill...
1,3 While HSCs can be activated directly in various aetiologies of chronic liver disease, inflammatory cytokines and the inflammation-related cellular and mediator milieu is the key driving force of fibrosis progression in the liver. Cirrhosis results from cumulative severe liver injury leading to ...
Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate regulation of miRNAs in chronically damaged fibrotic liver. MiRNA profiling shows that expression of miR-378 family members...
liver diseasepediatricscirrhosisAutosomal recessive polycystic kidney disease (ARPKD) is a developmental disorder that mainly affects the kidneys and the biliary tract. Affected patients often have massively enlarged cystic kidneys as well as congenital hepatic fibrosis (CHF) characterized by dilated bile ...
Liverfibrosisis achronic liver diseasecaused by many stimulatory factors; the production of excessive extracellular matrix (ECM) proteins results in the formation of scar tissue that affects liver function and results in liver cirrhosis [1]
With great advancements in the therapeutic modalities used for the treatment of chronic liver diseases, the accurate assessment of liver fibrosis is a vital need for successful individualized management of disease activity in patients. The lack of accura
LSECs play a crucial part in the cellular crosstalk that regulates progressive chronic liver disease, which leads to fibrosis and carcinogenesis. The role of LSECs in initiating immune responses and contributing to progressive liver disease makes them a potential therapeutic target for treating inflammat...