2Among the functionally different cell types identified, the hepatocytes (parenchymal cells) contribute more than 90% to the total volume occupied by liver cells.3,4The nonhepatocytes or non-parenchymal cells are much smaller than the hepatocytes and constitute about 40% of...
The liver has multiple functions. It makes many of the chemicals required by the body to function normally, breaks down and detoxifies substances in the body, and it also acts as a storage unit. Hepatocytes (hepar=liver + cyte=cell) are responsible for making many of the proteins (protein...
Ch 8.Cell Growth & The Process of Cell... Ch 9.The Nucleotide Structure of DNA &... Ch 10.Processes & Steps of DNA... Ch 11.Transcription, Translation & Protein... Ch 12.Types & Effects of Genetic... Ch 13.Mendelian Genetics & Mechanisms of... ...
The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science 369, 1388–1394 (2020). CAS PubMed PubMed Central ADS Google Scholar Xin, H. et al. A multi-tissue multi-omics analysis reveals distinct kinetics in entrainment of diurnal transcriptomes by inverted...
The liver is composed of five major cell types, and the hepatocyte is the most abundant cell type. Hepatocytes comprise approximately 70% of the liver cell population and are responsible for most metabolic and hormonal processes. The other four cell types, collectively known as hepatic non-parench...
The mammalian liver is a complex organ consisting of diverse cell types that perform multiple physiological functions including digestion, synthesis, metabolism, and detoxification. It also acts as an immune organ and plays a crucial role in anti-infection, autoimmune stability, and anti-tumour effects...
we addressed this limitation by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution. These transcriptomic analyses revealed that sequential cell-to-cell interactions direct functional maturation of hepatocytes, with non-parenchymal cells pl...
cell type in the liver is biliary epithelial cells (BECs),cholangiocytes. These two types of epithelial cells are derived from the commonprogenitor cell, which is also consideredliver stem cell. Tissue stem cells are generally defined as the cells having the potentials to self-renew and ...
the liver, a photolithographic cell patterning technique (‘micropatterned co-culture') has enabled the optimization of liver-specific functions in co-cultures via engineering of the balance between homotypic (hepatocyte-hepatocyte) and heterotypic (hepatocyte-non-parenchymal) cell-cell interactions [50]....
Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, ...