Within this set of cell types, we suspect that the observation of platelets as a majority cell type, rather than megakaryocytes2, likely reflects annotation differences in reference data. We observed distinct transcriptional contributions from solid tissue-specific cell types from the intestine, liver...
Kanel GC. Liver: anatomy, microscopic structure, and cell types. In: Yamada T, Alpers DH, Kalloo AN, Kaplowitz N, Owyang C, Powell DW, editors. Textbook of gastroenterology. 5th ed. Oxford: Wiley-Blackwell; 2009. p. 2057–72.Kanel GC. Liver: anatomy, microscopic structure, and cell ...
Our work shows that the efficacy and safety of colchicine depend on its selective action on hepatocytes, and reveals a new axis of liver–myeloid cell communication. Plasma GDF15 levels and myeloid cell SHP-1 activity may be useful pharmacodynamic biomarkers of colchicine action. This is a ...
The mammalian liver is a complex organ consisting of diverse cell types that perform multiple physiological functions including digestion, synthesis, metabolism, and detoxification. It also acts as an immune organ and plays a crucial role in anti-infection, autoimmune stability, and anti-tumour effects...
Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, ...
The hepatocytes, constituting ∼70% of the liver mass, are arranged in unicellular plates along the sinusoid where they experience homotypic cell interactions. Several types of junctions (i.e., gap junctions, cadherins, and tight junctions) and bile canaliculi at the interface of hepatocytes ...
Define liver cell cancer. liver cell cancer synonyms, liver cell cancer pronunciation, liver cell cancer translation, English dictionary definition of liver cell cancer. Noun 1. hepatocellular carcinoma - carcinoma of the liver hepatocarcinoma, hepatoma,
Liver cancer (LC) is presented as third leading cause of cancer-associated mortality, with 905,677 new cases and 830,180 new deaths in the world in 2020 [61]. The most common types of the liver cancers are hepatocellularcell carcinoma(HCC) and intrahepaticcholangiocarcinoma[61]. ...
we addressed this limitation by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution. These transcriptomic analyses revealed that sequential cell-to-cell interactions direct functional maturation of hepatocytes, with non-parenchymal cells pl...
The liver is a major metastatic site (organ) for gastrointestinal cancers (such as colorectal, gastric, and pancreatic cancers) as well as non-gastrointestinal cancers (such as lung, breast, and melanoma cancers). Due to the innate anatomical position of