These models include hepatocytes cultured as monolayer, collagen-sandwich; emerging complex 3D configuration; liver-derived cell lines; stem cell-derived hepatocytes. EXPERT OPINION: In vitro toxicity assays performed in hepatocytes or hepatoma cell lines can potentially provide rapid and cost-effective ...
We have studied the antiviral activities of five recombinant interferon-alpha (IFN-α) subtypes, namely IFN-α1, -α2, -α5, -α8 and -α10, in eight human liver cancer cell lines. The relative antiviral activities, expressed in terms of the mean 50% inhibitory concentration (IC50), wer...
Liver Cell Heterogeneity: Functions of Non-Parenchymal Cells The normal hepatic sinusoid is formed or lined by four different cell types, each with its specific phenotypic characteristics, functions and topography. Endothelial cells constitute the closed lining or wall of the capillary. They conta......
In a mature organism, tissue homeostasis is regulated by cell division and cell demise as the two major physiological procedures. There is increasing evide
In some histologic overlapping cases of FNH and HCA the morphologic diagnosis may be very difficult or even impossible (especially in small lesions) and molecular biology may be of critical assistance. A prototypical case of surgically resected multiple spontaneous liver cell adenomas of various types...
Liver cells in spite of having a very low mitotic rate in adult rats, undergo cell division following a variety of events. The hepatocyte growth responses are of particular interest not only because they take place in vivo in cells normally quiescent but also because they play important roles ...
Similarly, cyclic ovarian activity is key to reproductive success and profound changes in tissue composition. Its function requires exquisite spatiotemporal coordinated proliferation, apoptosis and differentiation of many different cell types within follicles, corpora lutea and ovarian stroma30. Sugiura et ...
6.2 – Cell Proliferation and Apoptosis in the Liver of Mice with Different Genetic Susceptibility to Tumor Induction and Its Control by Food and TGF-β1 Cell Proliferation and Apoptosis in the Liver of Mice with Different Genetic Susceptibility to Tumor Induction and Its Control by Food and TGF...
Hepatic stellate cells (HSCs) are considered the principal matrix-producing cells of the damaged liver. However, other cell types of the fibroblast lineage that have not yet been characterized are also involved in liver tissue repair and fibrogenesis. We established cultures of cells of the ...
Conclusions: Our study clarifies the cellular hierarchy in human megakaryocyte/erythroid lineage commitment and highlights the importance of using a combination of single-cell approaches to dissect cellular heterogeneity and identify rare cell types within a population. We present a novel immunophenotyping ...