and it is excreted unchanged by the kidneys (reminiscent of the kinetic patterns of water-soluble β-blockers). Therefore it can be given a class of its own, Class III. The half-life is sufficiently long to give a duration of action exceeding 24 hours. Once-daily dosing forCHFis licensed...
Data from the GISSI-3 post-myocardial infarction trial show that lisinopril reduced mortality and left ventricular dysfunction when given for 42 days starting within 24 hours of the onset of infarction symptoms. Results at 6 weeks and 6 months were similar in elderly and younger patients. Elderly ...
The first orally activeACEinhibitor was the drugcaptopril, which was released commercially in 1981.3Captoprilis a sulfhydryl-containing compound, with a fast onset but not especially sustained duration of action. The more long-actingACE inhibitorenalaprilmaleate was cleared for release by the Food and...