Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic...
and with different mechanisms of action have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits...
The first orally activeACEinhibitor was the drugcaptopril, which was released commercially in 1981.3Captoprilis a sulfhydryl-containing compound, with a fast onset but not especially sustained duration of action. The more long-actingACE inhibitorenalaprilmaleate was cleared for release by the Food and...
Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported in patients treated with angiotensin-converting enzyme inhibitors, including lisinopril. This may occur at any time during treatment. ACE inhibitors have been associated with a higher rate of angioedema in bla...
2. In guinea-pig atria, lisinopril (0.001-1 microM) exerted a negative inotropic effect which was accompanied by a shortening of the time to peak tension and time for total contraction. However, it did not modify atrial rate or the characteristics of the ventricular action potentials recorded ...
The dosage form can control the release, avoid dose dumping and extend the duration of action of a drug with prolonged floating time. Keywords: Lisinopril Dihydrate, Floating matrix tablet, HPMC K100, HPMC K15, HPMC K4MPrasantha kumari Mantada...