DrugOnset/Duration (h)Peak Hypotensive Effect (h)ProteinaBinding (%)Plasma Half-Life (h)Eliminationb Benazepril1/242–4>9510–11Renal/some biliary Captopril0.25/dose-related1–1.525–30<2Renal as disulfides Enalapril1/244–65011Renal Fosinopril1/242–69511Renal=hepatic ...
Data from the GISSI-3 post-myocardial infarction trial show that lisinopril reduced mortality and left ventricular dysfunction when given for 42 days starting within 24 hours of the onset of infarction symptoms. Results at 6 weeks and 6 months were similar in elderly and younger patients. Elderly ...
OnsetFollowing a single oral dose, antihypertensive effects observed within 1 hour, with peak blood pressure reduction at 6 hours.DurationAntihypertensive effect of a single dose persists for about 24 hours; effect at 24 hours substantially smaller than at 6 hours after dosing....
Data from the GISSI-3 post-myocardial infarction trial show that lisinopril reduced mortality and left ventricular dysfunction when given for 42 days starting within 24 hours of the onset of infarction symptoms. Results at 6 weeks and 6 months were similar in elderly and younger patients. Elderly...
new onset of cardiomyopathy, defined by an EF of less than 55% onechocardiography. The results did not show any difference between the effects of lisinopril versus losartan on EF improvement in the study population. Each drug was safe and significantly improvedsystolic functionat 1 year....