The principle of gene therapy is simple鈥擲upplement the body cells with the corrected copies of the malfunctioning genes. However, efficient delivery and expression of genes into body cells (a process biologists call transfection) is always easier said than done. Developing an efficient gene ...
The challenge of liposomes in gene therapy Summary Recently, liposomes have gained a special interest as gene delivery systems: over 30 human clinical trials for gene delivery using cationic liposom... F Martin,T Boulikas 被引量: 25发表: 1998年 Research and application of liposomes in gene th...
gene technologyliposomesnucleic acidsdrug deliverynonviral gene deliveryIn gene therapy, genetic materials, such as plasmid DNA, antisense oligonucleotides (asODNs), and small interfering RNA (siRNA), can be used to treat or prevent disease. This includes replacing a mutated gene, inactivating a ...
Creative Biostructure has established an advanced Mempro™ Liposome platform to suit a specific application such as gene therapy.
Liposomes for gene therapyGuidelines for submitting commentsPolicy: Comments that contribute to the discussion of the article will be posted within approximately three business days. We do not accept anonymous comments. Please include your email address; the address will not be displayed in the posted...
Liposomes as a gene delivery system. Gene therapy is an active field that has progressed rapidly into clinical trials in a relatively short time. The key to success for any gene therapy strate... ROPERT,C. - 《Brazilian Journal of Medical & Biological Research》 被引量: 106发表: 1999年 Ca...
Printed in Great Britain. Q 1998 IUPAC Liposomes: from membrane models to gene therapy Francis Schuber, Antoine Kichler, Christophe Boeckler and Benoit Frisch Laboratoire de Chimie Bioorganique, URA CNRS 1386, Universite Louis Pasteur, Faculte de Pharmacie, 74 route du Rhin, 67400 IIlkirch, ...
LiposomesGene TherapyMagnetic Resonance SpectroscopyThe mechanism whereby cationic lipids destabilize cell membranes to facilitate the intracellular delivery of ... IM Hafez,N Maurer,PR Cullis - 《Gene Therapy》 被引量: 610发表: 2001年 Lipoplex size is a major determinant of in vitro lipofection effic...
Define Liposomes. Liposomes synonyms, Liposomes pronunciation, Liposomes translation, English dictionary definition of Liposomes. n. A microscopic artificial vesicle consisting of an aqueous core enclosed in phospholipid molecules, used to convey vaccine
Presently, significant in vivo applications of liposomal ultrasound-based drug and gene delivery are being made in cardiac disease, stroke and tumor therapy. Translation of these vehicles into the clinic will require a better understanding of improved physical properties to avoid rapid clearance, as ...