Liposomes encapsulating PSA promoter-driven perforin expression vector (pLipo) were constructed for its specific expression in PC. The anti-tumor effect of pLipo was evaluated in vitro using docetaxel-resistant PC 22Rv1 PC cell line, 22Rv1DR, and PC-3 cells in the presence of human ...
The technique of targeted expression of interesting genes, including distinct delivery systems and specific gene promoter-operating expression, is an important strategy for gene therapy against cancers. Up to now, extensive literature documented the efficacy of distinct delivery systems, such as the ...
suggestingnon-viralvectors aresuperiortoadenoviralvectorsforIP-genetherapy. PublishedbyElsevierIrelandLtd. Introduction Pancreaticcancerremainsaterribleandchallengingdisease,rep- resentingonly2.8%ofnewcancersbutultimatelyresponsiblefor 6.8%ofallcancerdeaths[1].Pancreaticcancerhasdemonstrated remarkableresistanceto...
Mizuno M, Yoshida J, Sugita K, Inoue I, Seo H, Hayashi Y, Koshizaka T and Yagi K (1990) Growth inhibition of glioma cells transfected with the human interferon gene by liposomes coupled with a monoclonal antibody. Cancer Res 50: 7826–7829. Google Scholar Montes H and Hynynen K (1995...
Systemic delivery of cationic liposome-complexed plasmids targeting FAK, resulted in the diminishment of subcutaneous tumor growth beyond the effects observed with liposomes carrying a non-specific shRNA. This diminishment in growth was associated with elevated levels of apoptosis (TUNEL staining), ...
Cancer Gene Ther 3: 11–17 PubMed CAS Google Scholar Isaka Y, Akagi Y, Kaneda Y, et al (1998) The HVJ liposome method. Exp Nephrol 6: 144–147 Article PubMed CAS Google Scholar Gaber MH, Wu NZ, Hong K, et al (1996) Thermosensi-tive liposomes: extravasation and release of ...
Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example, as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt. Liposomes and emulsions are well known exa...
The limitations of currently available eukaryotic promoters include the fact that they lack sufficient activity when used to induce expression of proteins, are too large to be packaged into adenoviral vectors for in vivo gene delivery, or succumb to promoter “turn-off” by inflammatory factors elabo...
GP73-modified liposomes targeted gene delivery to the tumor tissue, and the survivin promoter drove HSVtk expression in the HCC cells. Our results showed that the survivin promoter was specifically activated in tumor cells and HSVtk was expressed selectively in tumor cells. Combined with GCV ...
Cyclin a promoter specific gene expression in hepatoma using asialofetuin (AF)-liposomesrupture of the spleenacute pancreatitischronic pancreatitissplenectomypancreatectomyBackground: Accessory spleen is a common congenital anomaly. There are currently no endoscopic ultrasound (EUS) criteria for the diagnosis...