Indeed, TREM2-expressing human LAM cells constituted a defined cluster (Figure S5B) that was characterized by a highly conserved gene signature compared with what we had observed in mice, including LIPA, CTSB, CTSL, FABP4, FABP5, LGALS3, CD9, and CD36 (Figure 3D). To further explore ...
Membrane-gated channels correspond to what have been called voltage-dependent channels; they are activated by the movements of particles that do not leave the membrane. Externally gated channels are equivalent to transmitter-activated channels; they are activated by agents, like acetylcholine, on the ...
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1d). This strong metabolic rewiring at the protein level raised the questions as to what extent this is reflected in the lipidome and if this multiomics-derived information can be used to generate novel hypotheses. Fig. 1: Global proteomics analysis highlights key changes of proteins steering ...
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Acute 18:1 exposure increased cellular cAMP levels similar to what was previously reported (Lim et al., 2013); however, non-loaded, acutely loaded, and overnight loaded cells all exhibited similar levels of cellular cAMP upon treatment with isoproterenol/IBMX (Figure 3H). Thus, in the ...
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The obtained pulse energy of a few millijoules at 1197 nm is comparable to what has been used for IVPA imaging22,23. The above data demonstrated that 1197 nm excitation with a nanosecond pulse duration can be achieved at a 2 kHz repe- tition rate, which is two orders of magnitude higher...
What is claimed is: 1. A method of treating a dermatologic condition in a human subject, comprising the step of administering to said subject a compound represented by the structure of the general formula (I): wherein R1 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl ...
What is claimed is: 1. A method of extracting lipid bound sialic acid from human blood plasma or serum and determining the amount of lipid bound sialic acid in a sample of human blood plasma or serum which comprises the following steps: ...