CEA was originally described as a colon-cancer-associated antigen, and tests for blood levels of CEA antigen are used to clinically monitor the progression of colon cancer. There are about 20 related proteins known; their genes are clustered on human chromosome 19, they belong to the Ig ...
Fasting blood samples were collected on the first day (D1) and after 30 days (D30). Lipidomic analysis was performed using the Lipidyzer platform. Similar classic lipid profile was obtained in both groups of lipid-lowering therapies. However, differences with the lipidomic analysis were ...
Research supported by grant U01 HL122703 from the National Heart Lung Blood Institute of NIH. Omics analyses were performed in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the US. Department of Energy and located at Pacific Northwest National Laborator...
(LBB). After arrival at the LBB the samples were centrifuged (CSF: 2000 g, 10 min, 23 °C; blood: 3100 g, 10 min, 23 °C) and the supernatants were aliquoted and snap-frozen in a controlled nitrogen environment using an ASKION C-line work bench (ASKION GmbH, Germany). The sample...
Glucose tolerance test Mice were fasted for 14 h and subsequently given 200 μl of a 0.1 g/ml (10%) glucose solution (JT Baker) by intraperitoneal injection. Blood glucose was determined at 0, 15, 45, 30, 60, 90 and 120 min post injection (Contour blood glucose meter, Baye...
On the contrary, oxidized cholesterol derivatives can easily diffuse across the blood brain barrier and may pro- vide a mechanism of interaction between central and peripheral cholesterol pools. These derivatives include 24S-hydroxycholesterol, which appears to be involved chiefly in excretion of excess ...
The majority of the cholesterol utilized for progesterone biosynthesis in cattle comes from the blood in the form of high-density lipoprotein-derived cholesteryl esters with smaller amounts from low-density lipoprotein5. Lipoproteins are internalized either through receptor-mediated endocytosis or selective...
However, they only occur with a frequency of 0.2% when compared with other nucleated blood cells, making them difficult to study. The entire process of megakaryopoiesis is accompanied by a substantial membrane reorganization, including shaping a lobulated nuclear envelope, packing granules, generating...
Methods of the invention use magnetically responsive particles for the rapid removal of lipoproteins that have been selectively precipitated from an aqueous medium such as blood, plasma, or serum. Preferred embodiments provide enhanced fractionation by selective precipitation of lipoproteins of one or more...
In another embodiment, anti-oxidant action may limit oxidative damage to cell and blood components arising in the course of a dermatologic condition. In another embodiment, attenuation of chemokines levels may attenuate physiological reactions to stress that arise in the course of a dermatologic ...