Results Here, we present Lipid Pathway Enrichment Analysis (LIPEA), a web-tool for over-representation analysis of lipid signatures and detection of the biological pathways in which they are enriched. LIPEA is a new valid resource for biologists and physicians to mine pathways significantly ...
i, KEGG pathway enrichment analysis showing upregulation of lipid metabolism-related pathways in epileptic mice. j-l, Heatmap and histogram showing significantly elevated lipids such as TGs, DGs, and CEs in the epileptic mice. For b-g, i, k-l, data represent the mean ± SEM, n ...
Enrichment analysis highlighted the lipid binding pathways as associated with Aβ deposition in brain driven by PITPNM3 (P = 4.27 × 1003), APOE (P = 2.45 × 1010), AP2A2 (P = 1.06 × 1003), and SH3GL1 (P = 7.56 × 1004). Overall, our data strongly support a connection between ...
4g). Based on the TCGA HCC database, a pathway enrichment analysis also showed that USP22 was significantly correlated with the PPAR pathway in HCC (Fig. 4h). Overall, our results confirm that USP22 specifically interacts with PPARγ, which is a key transcription factor related to lipid ...
(Fig.4B). In addition, GeneSet Enrichment Analysis (GSEA) analysis also indicates the negative regulation of PPAR pathway after ACSL3 silencing (Fig.4C). With this information, we further analyzed the DEGs in the PPAR signaling pathway enriched in KEGG analysis. As presented in Fig.4D, the ...
Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pathway through an unknown mechanism. Herein, we identify that monounsaturated fatty acids (MUFAs) allosterically activate SIRT1 toward select peptide-substrates such as PGC-1α. MUFAs enhance PGC-...
Pathway enrichment analysis of DEGs was performed with gene ontology analysis. Data were deposited in the NCBI Gene Expression Omnibus under accession number GSE193731. Protein Extraction and Immunoblotting Immunoblotting was performed as described previously.17 Cell or tissue samples were lysed in RIPA...
(Doc). No 7-methyl-docetaxel was observed in any sample, which has been proposed as a possible metabolic pathway, and also no 7-epi-docetaxel. The latter was investigated based on previous observations of the very significant C7 epimerization found to occur in the analogous paclitaxel molecule ...
6b). The single region deviating substantially from this relationship was the piriform cortex—an entry point of the odor sensation pathway (Fig. 6b). Further, individual lipid intensities correlated with HR well above the chance expectation (HR lipids, N = 60, lm(lipid intensity ~ ...
Pathways were sorted by their fold enrichment independent of the number of proteins involved. Pathway enrichment analysis was performed using the open-source DAVID bioinformatics tool. f,g, Bar graphs of various MK differentiation markers (f) and lipid-related enzymes (g) displayed with their ...